Name:                                        STEPHEN TOWNLEY HOLGATE

Date of birth:                        2nd May 1947

Place of Birth:                     Heywood, Lancashire

Address:                                Infection, Inflammation and Repair Division, Mailpoint 810

                                                Level F, South Block, Southampton General Hospital, Southampton SO16 6YD

                                                Tel: 02380 796960; Fax: 02380 701771, e-mail: sth@soton.ac.uk

Present post:        (i)            Medical Research Council (Clinical) Research Professor of Immunopharmacology (from 1987)

                                (ii)           Honorary Consultant Physician, Southampton University Hospitals Trust             

Department/Group:             Allergy and Inflammation Repair (AIR), Infection, Inflammation and Repair Division

Faculty:                                 Faculty of Medicine, Health and Biological Sciences

Date of appointment/promotion to present post:  1 June 1987

DEGREES and QUALIFICATIONS

               1968         BSc                        Biochemistry (Class I)                                 London University

1971        MB BS                  Medicine/Surgery                                                      London University (Charing Cross Hospital)

                1973        MRCP    (UK)                                                                              Royal College of Physicians

                1979        MD                         Asthma Research                                        London University                                                      

                1984        FRCP                                                                                           Royal College of Physicians of London

                1991        DSc                         Inflammatory Basis of Asthma                  University of Southampton

                1995        FRCP (Edin)                                                                               Royal College of Physicians of Edinburgh

                1997        FMedSci                                Foundation Fellow                                      Academy of Medical Science

            1999        CBiol FIBiol                                                                            Institute of Biology (Hon)

                1999        FRCPath                                                                                     Royal College of Pathologists (Hon)

PREVIOUS APPOINTMENTS        

                1971 - 1972             House Physician, Charing Cross Hospital, London

                1972 - 1973             Senior House Officer (Neurology), National Hospital for Nervous Diseases, London

                1973 - 1974             Senior House Officer Respiratory Medicine & Cardiology, Brompton Hospital, London      

                                1974 - 1975             Registrar (General Medicine), General Infirmary, Salisbury & Southampton General Hospital

                                1975 - 1980             Lecturer and Hon Senior Registrar in Medicine, Southampton General Hosp and Western Hospital

                1978 - 1980             MRC and Wellcome Trust Overseas Research Fellow, Harvard University, Boston, USA 

                1975 - 1980             Lecturer in Medicine and Honorary Senior Registrar

                1980 - 1986             Senior Lecturer, Reader then Professor of Medicine and Hon Consultant Physician                         

HONOURS AND DISTINCTIONS 

                1978        Medical Research Council Dorothy Temple Cross & Wellcome Trust Travel Fellowship

                1990        Philip Ellman Lecturer, Royal College of Physicians

                1991        The Hurst Brown Visiting Professorship, University of Toronto, Canada

                                The Altounyan Lecture, British Thoracic Society

                1992        The Cournand Lecture, European Respiratory Society

                1993        James-Parkinson Memorial Lecture, Society of Occupational Medicine

                                The Annual Thomas Young Medal, St George's Hospital, London

                                The Royal College of Physicians Graham Bull Prize for Clinical Research

                1994        The Lilly Lecture, Royal College of Physicians of Edinburgh

                                The CIBA Foundation Lecture, Science Festival, Edinburgh

                                The Jack Pepys Lecture, British Society for Allergy and Clinical Immunology

                Scientific Achievement Award, International Association of Allergy and Clinical Immunology,Stockholm

                1995        Robert Cooke Memorial Lecture, American Academy of Allergy and Immunology

                                Visiting Professor, Ontario Thoracic Society, Canada

                                Rhône-Poulenc Rorer World Health Award ($20,000)

                1996        Honorary Fellow, South African Pulmonology Society

                                The Priscilla Piper Memorial Lecturer, Royal College of Surgeons

                                Honorary Member, Nordic Society of Allergology                       

                                Evening Discourse, Royal Institution of Great Britain

                                Visiting Professor, Vanderbilt University, USA

                1997        Visiting Professor, Harvard University, Boston, USA                  

                                Doctorate Hon Causa, University of Ferrara, Italy      

                1998        Visiting Professor, University of Rochester USA

                                Brian Sproule Lecture, University of Alberta, Canada

                               Doctorate Hon Causa, Jallegonian University, Krakow, Poland

1999            King Faisal International Prize in Medicine (Gold Medal, $200,000 - shared with Patrick Holt, Australia)

                                Medal for Scientific Achievement, Rijksuniversity, Gent, Belgium

                                Ranked No.8 in UK Citations in Biomolecular Subjects (ISI), 1990-2000

2000            Lumleian Lecture, Royal College of Physicians

                Robert Cooke Memorial Lecture, American Academy of Allergy, Asthma and Immunology

                               Honorary Member, Germany Society for Pulmonology

                                Alec Sehon Distinguished Professorship in Allergy, University of Manitoba, Canada

                2001        Visiting Professor, Yale University School of Medicine

                                The Honorary Fellow Award, American Academy of Allergy, Asthma & Immunology                        

                                Visiting Professor, Harvard Medical School, Boston, USA

                                Czech Republic Medical Society Medal for Scientific Achievement, Prague

                                Overseas Fellow, Polish Academy of Science

                                ISI Most Highly Cited Researcher for Publications 1980-2000

                                Visiting Professor, Thomas Jefferson Medical College, Philadelphia, USA

2002        Visiting Professor, University of Cincinnati Medical Center, USA

                Norman Sterrie Lecture, University of Minnesota, USA

Highly Cited Researcher (Original Member, Highly Cited Researchers database, ISI)

2003             Sir William Osler Lecture, Association of Physicians of GB and Ireland

2004             Ellison-Cliffe Medal, Royal Society of Medicine

                GB West Memorial Lecture, European Histamine Research Society

                Scientific Achievement Award, International Association of Asthmology (Interasma)

2004        Visiting Professor, University of Michigan, Ann Arbor, USA

Visiting Professor, Wake Forest University, Winston-Salem, N Carolina, USA

                                Health and Life Sciences Gold Medal, Rijksuniversity, Gent, Belgium

                                Honorary Member, Association of Physicians of Great Britain and Ireland

                                Honorary Fellow, American College of Asthma, Allergy and Immunology (ACAAI)

                                Honorary Member, Biochemical Society

                                The British Pharmacological Society Quintiles Prize in Immunopharmacology 

                                Hospital Doctor Academic Medicine Team of the Year Award

                2005        Member, American Association of Physicians (AAP)

                                Visiting Professor, University of British Columbia, Canada

                                Visiting Professor, UCSF and the Sandler Asthma Foundation, USA

                                Sir Anthony Dawson lecture, Royal London and St Bartholomew’s Hospitals

2006           The Huxley Lecture, Imperial College, London

                               The Burns Lecture, RCP Glasgow

Honorary Member, DGAKI (German Society of Allergy and Clinical Immunology)

President of the British Thoracic Society

2007         Visiting Professor, John Hopkins Bloomberg School of Public Health, Baltimore, USA

                                 Visiting Professor Harvard Medical School, Boston and Ohio State, University, Ohio, USA

                                BMA Medical Book of the Year Award for Allergy 3^rd edition

                                Royal Society of Medicine Book Commendation for Allergy 3^rd edition

2008        Paul Ehrlich Award for Research, European Academy of Allergy, Asthma and Clinical Immunology

2009        Opening Plenary Lecture, Keystone Conference on Asthma and Allergy

JOURNAL EDITORSHIPS

                                Clinical Experimental Allergy (since 1984); Clinical Science - Associate Editor;

                                Current Allergy and Asthma Reports;

                                Current Opinion in Allergy and Immunology;                Drug Targets in Allergy and Inflammation - Associate Editor.

EDITORIAL BOARDS (Last 5years)

J. Allergy Clin Immunol, Clinical and Experimental Immunology, Thorax, Allergology International, American Journal of Respiratory Medicine, American J Respiratory Cell and Molecular Biology, Canadian Respiratory Journal, Chinese Journal of Respiratory and  Critical Care Medicine, Current Allergy Reports Current Medical Literature, Current Opinion in Pulmonary Medicine, Genes and Immunity, Immunology and Medicine Series International Journal of Clinical and Laboratory Research, International Journal of Pharmaceutical Medicine, International Review of Allergology and Clinical Immunology, International Editorial Board of Minerva Medica, Journal of Drug Evaluation, Journal of Drugs in Respiratory Disorders, International Advisory Board of the International, Journal of Clinical & Laboratory Research, BioMed Central Pulmonary Medicine, Encyclopaedia of Respiratory Medicine, Scientific World Journal, Journal of Clinical Immunology, Expert Opinion on Drug Safety, BMC Medicine, Clinical and Development Immunology, Purinergic Signalling, Iranian Journal of Allergy, Asthma and Immunology, Allergy and Asthma Proceedings, Personalized Medicine, Issues in Environmental Science and Technology, BMC Proceedings.     

INDEPENDENT COMMITTEES

1999 - 2001          Special Adviser, House of Lords Select Committee on Science and Technology Sub-Committee 1

2001 - 2008          Member, Royal Commission on Environmental Pollution (renewed 2005)

2004 - present      Chairman, Science in Health Group of the Science Council

2008                     Founding member, All Party Parliamentary Group on Allergy

HIGHER EDUCATION FUNDING COUNCIL

2000 - 2001            Member, Research Assessment Exercise (RAE) 2001 Panel Units of Assessment 5-8 Pre-clinical Studies        

OFFICE OF SCIENCE AND TECHNOLOGY AND DIUS

1994 - 1997          Member, Health and Life Sciences Panel of the Technology Foresight Programme

1997 - present      Member, Office for Strategic Coordination of Health Research of Research (OSCHR)

                              Translational Medicine Board

GOVERNMENT DEPARTMENTS

1990 - 1993             Member, DH Committee for the Safety of Medicines (CSM) Sub-Committee on Efficacy and Adverse Reactions

1990 - 2003          Chairman, now member of DH Committee on the Medical Effects of Air Pollutants (COMEAP)

1992 - 2000             Member, DH Advisory Committee on NHS Drugs

1992 - present      Member, now Chairman of DEFRA Expert Panel on Air Quality Standards (EPAQS), incorporated as a

                               subpanel of COMEAP, 2008 (Chair)

1995 - 1997             Member, NHS Central Research and Development Committee (CRDC)

1992 - 1996           Director of NHS R & D, Wessex Regional Health Authority

2005 - present      Member, FSA Advisory Committee on Novel Foods and Processes

2008                     Chairman, DEFRA Advisory Committee on Hazardous Substances

MEDICAL RESEARCH COUNCIL

1989 - 1993             Member, then Chairman Grants Committee A, Physiological Medicine and Infections Board

1991 - 1995             Member, Physiological Medicine and Infections Board

1991 - 1993             Member of Panel, Non-Clinical Senior Fellowships

2000 - 2003             Member, then Deputy Chairman of the Cross Board Group (Cooperative Group Grants)

2004 - 2006             Member, Subcommittee on Strategy, Corporate Policy and Evaluation (SCoPE).

2003 - 2004             Member, MRC Clinical Research Advisory & then Oversight Group (CRAG & CROG)

2005 - 2008             Member, MRC Clinical Research Oversight Group (CROG)

2005 - 2008          Chairman, Council Subcommittee on Evaluation

2007 - present      Chairman, MRC Physiological Systems and Clinical Sciences Board (renamed: Population Sciences and

                               Medicine Board)

2007 - present      Member, MRC Strategy Board

2008                       Member, Pharmaceuticals Forum

ROYAL COLLEGE OF PHYSICIANS

1994 - 1995             Censor, RCP         

1994 - 1996             Member, RCP Working Party on Priorities in the NHS

1996 - present      Member, Board of Examiners of the Faculty of Pharmaceutical Medicine

2001 - 2003          Chairman, Working Party on Allergy - produced report “Allergy: The unmet need”

2003 - present      Member, Advisory Committee on Distinction Awards and National Honours

RESEARCH CHARITIES

1991 - 1997             Member, Council of the British Allergy Foundation

1992 - 1997             Member, Chairs and Research Groups of British Heart Foundation

1986 - 1997             Member, Research Committee of National Asthma Campaign

1993-2003               Member, then Chairman Research Advisory Committee of the Mason Family Medical Research Foundation

1994 - present       Member, Scientific Advisory Panel to the Norman Salvesen Emphysema Research Fund

1988 - present      Founder and Chairman of Trustees of Asthma and Allergy Inflammation Research Trust (AAIR)

1994 - present      Trustee, the Drug Safety Research Trust (DSRU), Southampton

1995 - 2004             Member, Scientific Co-ordinating Committee (SCC) and Chairman, Programme Grants Committee, Arthritis

                               Research Campaign (ARC)

2003 - 2004          Member, Novartis (formally CIBA) Foundation Scientific Advisory Panel

2004 - 2006          Member, Executive Council Novartis Foundation

2006 – 2008          Chairman, Executive Council  Novartis Foundation

2005 – present     Vice President, British Lung Foundation

2004 - present      Founder, then President of the National Allergy Strategy Group (NASG)

2008 - present      Vice President, Environmental Protection UK (formerly National Society for Clean Air)

2008 - present        Board of Governors, Stroud School, Romsey, Hants

IMNTERNATIONAL

1990 - present      Member, Council (until 1994) then Secretary General (2007) Collegium International Allergologicum (CIA)

1994 - 2004          Founder member, Executive Board of WHO/NIH Global Initiative for Asthma (GINA)

1996 - Present     Member, Board of UCB Institute of Allergy, Brussels, Belgium

2007 - present      Member, Executive Board of World Allergy Organisation (WAO)

1998 – present     Chairman, Merck International Respiratory Advisory Board (AIR).

1999 - 2000             Member, ATS and ALA World Lung Health Committee

2000 - 2001             Member of the Nomination Committee of the American Thoracic Society

2001 - 2005             Member, WHO project “Systematic Review of Health Aspects of Air Quality in Europe”

POSTGRADUATE SUPERVISION (MSc, MPhil, PhD, DM)

                Currently Supervised                        Supervised to successful completion

MSc                            0                                                                          3                                                                

PhD                            4                                                                          28                                                               

DM                             2                                                                         27

PUBLICATIONS

 865 Peer-reviewed publications, 52 Book editorships, 410 Book Chapters and Reviews, 46 Editorials, 63 Official and Government Reports.

GRANT INCOME

Continuous MRC grant support since 1987 with supplementary funding from Asthma UK, British Lung Foundation and Industry: average £1.2 million p.a.  over the last 5 years.

Key References

Stephen T Holgate

1. Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ.  Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study.  New England Journal of Medicine. 1990 Aug 23; 323(8): 502-7.

2. Holgate ST, Burns GB, Robinson C, Church MK.  Anaphylactic- and calcium-dependent generation of prostaglandin D₂ (PGD₂), thromboxane B₂, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release.  Journal of Immunology. 1984 Oct; 133(4): 2138-44.

3. Bradding P, Feather IH, Howarth PH, Mueller R, Roberts JA, Britten KM, Bews JPA, Hunt TC, Okayama Y, Heusser CH, Bullock GR, Church MK, Holgate ST.  Interleukin-4 is localised to and released by human mast cells.  Journal of Experimental Medicine. 1992 Nov 1;176(5):1381-6.

4. Bradding P, Okayama Y, Howarth PH, Church MK, Holgate ST.  Heterogeneity of human mast cells based on cytokine content.  Journal of Immunology. 1995 Jul 1; 155(1): 297-307.

5.      Hutson PA, Church MK, Clay TP, Miller P, Holgate ST.  Early and late-phase bronchoconstriction after allergen challenge of nonanesthetized guinea pigs. I. The association of disordered airway physiology to leukocyte infiltration. American Review of Respiratory Disease. 1988 Mar; 137(3): 548-57.

6. Hardy CC, Robinson C, Tattersfield AE, Holgate ST.  The bronchoconstrictor effect of inhaled prostaglandin D₂ in normal and asthmatic men.  New England Journal of Medicine. 1984 Jul 26; 311(4): 209-13.

7. Howarth PH, Durham SR, Lee TH, Kay AB, Church MK, Holgate ST.  Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma.  American Review of Respiratory Disease. 1985 Nov; 132(5): 986-92.

8. Holgate ST.  The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma.  British Journal of Pharmacology. 2005 Aug; 145(8): 1009-15.

9. Beasley R, Roche WR, Roberts JA, Holgate ST.  Cellular events in the bronchi in mild asthma and after bronchial provocation. American Review of Respiratory Disease. 1989 Mar; 139(3): 806-17.

10. Montefort S, Gratziou C, Goulding D, Polosa R, Haskard DO, Howarth PH, Holgate ST, Carroll MP.  Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways.   Journal of Clinical Investigation. 1994 Apr; 93(4): 1411-21.

11.  Djukanović R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR, Howarth PH, Holgate ST.  Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma.  American Rview of Respiratory Disease. 1992 Mar; 145(3): 669-74.

12. Cowburn AS, Sladek K, Soja J, Adamek L, Nizankowska E, Szczeklik A, Lam BK, Penrose JF, Austen FK, Holgate ST, Sampson AP. Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.  Journal of Clinical Investigation. 1998 Feb 15; 101(4): 834-46.

13. Corne J, Djukanovic R, Thomas L, Warner J, Botta L, Grandordy B, Gygax D, Heusser C, Patalano F, Richardson W, Kilchherr E, Staehelin T, Davis F, Gordon W, Sun L, Liou R, Wang G, Chang TW, Holgate S.  The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics.  J Clin Invest. 1997 Mar 1;99(5):879-87.

14.  Howarth PH, Babu KS, Arshad HS, Lau L, Buckley M, McConnell W, Beckett P, Al Ali M, Chauhan A, Wilson SJ, Reynolds A, Davies DE, Holgate ST.  Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma.  Thorax. 2005 Dec; 60(12): 1012-8. Epub 2005 Sep 15.

15.  Roche WR, Beasley R, Williams JH, Holgate ST.  Subepithelial fibrosis in the bronchi of asthmatics.  Lancet. 1989 Mar 11; 1(8637): 520-4.

16. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, Walsh A, Liu Z, Hayward B, Folz C, Manning SP, Bawa A, Saracino L, Thackston M, Benchekroun Y, Capparell N, Wang M, Adair R, Feng Y, Dubois J, FitzGerald MG, Huang H, Gibson R, Allen KM, Pedan A, Danzig MR, Umland SP, Egan RW, Cuss FM, Rorke S, Clough JB, Holloway JW, Holgate ST, Keith TP.  Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.  Nature. 2002 Jul 25; 418(6896): 426-30. Epub 2002 Jul 10.

17. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, Symington P, O'Toole S, Myint SH, Tyrrell DA, Holgate ST  Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. British Medical Journal. 1995 May 13; 310(6989): 1225-9.

18. Fraenkel DJ, Bardin PG, Sanderson G, Lampe F, Johnston SL, Holgate ST.  Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects.  American Journal of Respiratory and Critical Care Medicine. 1995 Mar; 151(3 Pt 1): 879-86.

19. Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, Holgate ST, Davies DE.  Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus.  Journal of Experimental Medicine. 2005 Mar 21; 201(6): 937-47.

20. Chauhan AJ, Inskip HM, Linaker CH, Smith S, Schreiber J, Johnston SL, Holgate ST.  Personal exposure to nitrogen dioxide (NO2) and the severity of virus-induced asthma in children.  Lancet. 2003 Jun 7; 361(9373): 1939-44.