ASTHMA Research Chair

NAME: Qutayba Hamid

DATE OF BIRTH: June 17, 1953

PRESENT ADDRESS: 885 Laird Boulevard

Town of Mount Royal, Quebec CANADA

MARITAL STATUS: Married with 4 children

NATIONALITY: Canadian

QUALIFICATIONS: MB ChB Mosul University (1978)

PhD (Faculty of Medicine), Univ. of London, UK

FRC Path (Fellow of the Royal College of Pathologists), London, UK

MRCP (Member of the Royal College of Physicians), London, UK

FRCP (Fellow, Royal College of Physicians), Canada

APPOINTMENTS:

September 2007 - Associate Member, Biochemistry Department

McGill University

September 2005 - MUHC Strauss Chair in Respiratory Medicine

McGill University Health Center

January 2001- James McGill Professor of Medicine and Pathology

McGill University, Montreal, Canada

June 1998-to date: Professor of Medicine and Pathology

McGill University, Montreal, Canada (Full Professor with tenure since 1997)

February 1999 - to date: Director, Respiratory Axis

McGill University Health Centre, Montreal, Canada

June 1993- to date: Research Director, Meakins-Christie Laboratories

McGill University

June 1993- May 1998: Associate Professor of Medicine and Pathology,

McGill University, Montreal, Canada

June 1993-April 2001: Service Director, Immunology Lab, Royal Victoria Hosp.,

Montreal, Canada

Attending Staff, Dept. of Medicine, Royal Victoria Hospital

February 1996- 2000: Associate Scientific Director, Respiratory Health- Network of Centres of Excellence (Inspiraplex), Montreal Chest Institute, Montreal, Canada

PREVIOUS APPOINTMENTS IN THE U.K. (1984-1993):

1984-1988: Fellow

Histochemistry Unit, RPMS

Hammersmith Hospital, London, U.K.

Oct 1988-Nov 1989: Lecturer

National Heart and Lung Institute

Brompton Hospital, London, U.K.

Nov. 1989-Nov. 1993: Clinical Lecturer/Senior Lecturer

Departments of Allergy and Clinical

Immunology & Pathology

National Heart and Lung Institute

Brompton Hospital, London, U.K.

RESEARCH EXPERIENCE:

Current areas of research interest

Pathogenesis of asthma and allergic inflammation
Cytokines and chemokines in asthma and allergic inflammation
Transcription factors in asthma
Airway remodeling in asthma and COPD
Immunotherapy and immunomodulation

Techniques

1. Immunocytochemistry

2. Culture Techniques

3. Receptor Localisation

4. Flow Cytometry

5. Molecular biology: This includes:

- Construction of genetic probes

- In situ hybridization

- Southern and Northern blot analysis

- Cloning

- PCR

- Gene manipulation techniques

- Tissue engineering

- Real-time PCR

- Laser capture

Teaching activities and supervision

London University, U.K.:

- Supervising the research programme of a number of researchers including PhD and MSc students and visiting fellows

- Teaching at the core courses for Ph.D. students at the University of London

- Selected as a recognized teacher for the University of London, Faculty of Medicine

McGill University, Montreal, Canada:

- Teaching at a number of McGill graduate courses (see recent lectures given)

- Currently supervising 4 graduate students (J. Al Jabri, D. Prefontaine, O. Roshdy, J. Nadigel) and 1 postdoctoral fellows (N. Takeda)

- Organizer, "Cytokines in Health and Disease Course" (546-607B), McGill University, January - April (3 credit graduate course)

International courses organized:

- Organized two international courses (1988/1989) on in situ hybridization at the Hammersmith Hospital, London, U.K.

- Organized the National Heart & Lung Institute international course of molecular pathology, London, U.K., September 1989

- Organized the “In Situ Hybridization” 2-day symposium (September 1996), Montreal, Canada

- Organized the “In Situ Hybridization & Immunocytochemistry” 2-day symposium (September 1997), Montreal, Canada

- Organized an International workshop on “Chemokines” (February 1998), Bromont, Quebec

- Organized an International workshop on “Chemokines and Cytokines Receptors” (February 1999), St. Sauveur, Quebec

- Organized an International workshop on “Interaction between Inflammation/Remodeling and Smooth Muscle”, (June 2000), Ste-Adele, Quebec, Canada

- Organized the Meakins-Christie/Hopital Laval Scientific Exchange on “Inflammation and Airway Remodeling in Pulmonary Diseases” (November 6-7, 2000), Universite Laval, Quebec City, QC.

- Organized an International workshop on “Pathogenesis and Treatment of Asthma and COPD: Current and Future Aspects” February 2001, Magog-Orford, Quebec, Canada

- Organized a 3M workshop on “The Role of Small Airways in Asthma: New Concepts in Pathophysiology and Treatment” (June 30-July 1, 2001), Magog-Orford, Quebec, Canada

- Organized the Meakins-Christie/Hopital Laval Scientific Exchange (January 21, 2002), Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada

- Organized an International Workshop on “Pathogenesis and Treatment of Asthma”, February

2002, Bromont, Quebec, Canada

- Organized the 6^th Annual Meakins-Christie Workshop on “Asthma and COPD”, February 2003, St. Sauveur, Quebec, Canada

- Organized the 7^th Annual Meakins-Christie Workshop on “Asthma and COPD”, February 2004, Bromont, Quebec, Canada

- Organized the 8^th Annual Meakins-Christie Workshop on “Asthma and COPD”, February 2005, Magog-Orford, Quebec, Canada

- Organized the 9^th Annual Meakins-Christie Workshop on “Asthma and COPD”, February 2006, Ste-Adele, Quebec, Canada

- Organized the Symposium on Obesity and Asthma, November 2006, Atwater Club, Montreal, Quebec, Canada

- Organized the 10^th Annual Meakins-Christie Workshop on “Asthma and COPD”, February 2007, St. Sauveur, Quebec, Canada

- Organized the Symposium on Sleep Apnea, October 2007, Atwater Club, Montreal, Quebec, Canada

- Organized the 11^th Annual Meakins-Christie Workshop on “Asthma and COPD”, February 2008, Magog, Orford, Quebec, Canada

Administrative Responsibilities

1997-present: Chairman, Montreal Chest Institute Research Committee, McGill University

1993- 1997: Chairman, Animal Ethics Committee, Meakins-Christie Laboratories, McGill University

1993-1997: Member, Montreal Chest Institute Research Committee, McGill University

1993-present: Member, Meakins-Christie Advisory Committee, McGill University

1993-present: Member, Meakins-Christie Fellowship Committee, McGill University

1996-1999: Associate Scientific Director, Inspiraplex, Montreal Chest Institute, McGill University

1997-2001: Member, Medical Research Council of Canada “Scholarship” Committee

1999-present: Member, Respiratory Committee, CIHR, Ottawa, Ontario

1999-present: Leader, Respiratory Axis, McGill University Health Centre, Research Institute

Membership in Professional Organization

1990-present: Member, Royal College of Physicians, London, United Kingdom

1997-present: Member, American Thoracic Society, American Lung Association, New York

1997-present: Member, American Academy of Allergy, Asthma and Immunology Association, New York

1998-present: Member, New York Academy of Sciences

1998-present: Member, American Association for the Advancement of Science

1998-present: Fellow, Royal College of Pathologists, United Kingdom

2002-present: Fellow, Royal College of Physicians, Canada

2006-present: Fellow, American Academy of Allergy, Asthma and Immunology

Editorial Board

2001-present: Canadian Journal of Allergy and Clinical Immunology / Section Editor

1996-2007: Journal of Clinical and Experimental Allergy

1998-2003: Thorax

1996-2001: Journal of Allergy and Clinical Immunology

2003-2008: Associate Editor, Journal of Allergy and Clinical Immunology

2008- Clinical and Experimental Allergy / Co-editor in chief

Referee for Journals

American Journal of Respiratory and Critical Care Medicine; American Journal of Respiratory Cell and Molecular Biology; International Archives of Immunology; Journal of Clinical Investigation; Journal of Immunology/PNAS; Nature, New England Journal of Medicine

Referee for Granting Agencies

2007-present: Member, ICRH Institute Advisory Board

2004-present: Member, Respiratory Committee, CIHR

Medical Research Council, United Kingdom

Welcome Trust, UK

Quebec Thoracic Society, Canada

F.R.S.Q. Quebec, Canada

Canadian Institutes of Health Care Research, Scholarships “D” Awards and Respiratory Committees

NIH, USA

Senior Scholarship Alberta Heritage Foundation

Parker B. Francis Fellowship Foundation

Honours and Awards

1987: ORS Award (from the Committees of Vice-Chancellors and Principals of the universities of the United Kingdom). The criteria for the award were outstanding merit and research. London, United Kingdom

1988: ORS Award, London, United Kingdom

1993: Pharmacia Research Award

1995: FRSQ Award (Fonds de la Recherche en Sante du Quebec)

1997: FRSQ Award (Fonds de la Recherche en Sante du Quebec)

1999: Pfizer Professorship Award

2001: James McGill Professor, McGill University, Montreal, Quebec, Canada

2001: FRSQ Senior Chercheur-Boursier Award (FRSQ)

2003: CSACI Award for Research in Immunology, Vancouver, Canada

2005: FRSQ Chercheurs-Nationaux Award

2005: MUHC Straus Chair in Respiratory Medicine

2007: Burton Zweiman Lectureship, 2007 AAAAI meeting, San Diego, CA, USA

Visiting Professor

1. Visiting Professor, National Centre for Immunology and Respiratory Medicine, Denver, Colorado, USA (1993)

2. Visiting Professor, Pasteur Institute, Lille, France (1994)

3. Visiting Professor, Washington University, Div. of Allergy and Immunology, St. Louis, MO (April 1995)

4. Visiting Professor, University of British Columbia, Pulmonary Research Laboratory, Vancouver, BC, Canada (August 1995)

5. Visiting Professor, McMaster University, Division of Clinical Immunology & Allergy, Hamilton, ON, Canada (June 1995)

6. Visiting Professor, Universite de Laval, Centre de Pneumologie de l’Hopital Laval, Sainte-Foy, QC, Canada (June 1995)

7. Visiting Professor, Yale University, Pulmonary and Critical Care Section, New Haven, CT, USA (October 1996)

8. Visiting Professor, Osaka University, Japan, (October 1998)

9. Visiting Professor, Kyoto University, Japan (October 1998)

10. Visiting Professor, University of Wisconsin-Madison Medical School, Madison, WI, USA (November 1998)

11. Visiting Professor, John Hopkins University, Baltimore, MD, USA (May 1999)

12. Visiting Professor, Institut Pasteur de Lille, France (August 2000)

13. Visiting Professor, University of British Columbia, Canada (February 2001)

14. Visiting Professor, University of Wisconsin-Madison Medical School, Madison, WI, USA (August 2001)

15. Visiting Professor, University of Toronto (November 2001)

16. Visting Professor, Sultan Qaboos University, Oman (January 2003)

17. Visiting Professor, Riyadh, Saudi Arabia, (January 2004)

18. Visiting Professor, Jeddah, Saudi Arabia (January 2004)

19. Visiting Professor, Jeddah, Saudi Arabia (November 2005)

20. Vising Professor, Riyadh, Saudi Arabia (March 2006)

21. Visiting Professor, Jeddah, Saudi Arabia (November 2006)

22. Visiting Professor, University of Chicago (June 2007)

23. Visiting Professor, Johns Hopkins University (June 2007)

24. Visiting Professor, University of Pennsylvania (June 2007)

25. Visiting Professor, Damascus University, Syria (July 2007)

26. Visiting Professor, Riyadh, King Saud University (September 2007)

27. Visting Professor, University of Leuven, Belgium (December 2007)

28. Visiting Professor, McMaster University, Canada (January 2008)

29. Visiting Professor, United Arab of Emirates (February 2008)

30. Visiting Professor, United Arab of Emirates (March 2008)

LECTURES PRESENTED – SELECTED LECTURES:

McGill University

1) Medical Grand Rounds, Royal Victoria Hospital, August 1993

"Cytokines in allergy and asthma" (2 hrs)

2) Interdisciplinary Respiratory Research Seminar, Meakins-Christie Laboratories, McGill University, November 1993

"Cytokines in steroid resistant asthma" (2 hrs)

3) Pathology Seminar, Department of Pathology, McGill University, December 1993

"Immunopathology of asthma" (2 hrs)

4) Cardiovascular course, McGill University, January 1994

"Molecular biology in cardiovascular research" (2 hrs)

5) Molecular Biology Techniques and Applications lecture no. 1, Meakins-Christie Laboratories, January 1994

"Molecular basis of hybridization" (2 hrs)

6) Molecular Biology Techniques and Applications lecture no. 2, Meakins-Christie Laboratories, February 1994

"RNA detection" (2 hrs)

7) Molecular Biology Techniques and Applications lecture no. 3, Meakins-Christie Laboratories, March 1994

"Protein detection" (2 hrs)

8) Advanced Applied Respiratory Physiology course, McGill University, March 1994

"Cell communications in the bronchial wall" (2 hrs)

9) Biochemistry Methodology course, McGill University, April 1994

"In situ hybridization" (2 hrs)

10) Molecular Biology Techniques and Applications lecture no. 4, Meakins-Christie Laboratories, April 1994

"PCR and in situ hybridization" (2 hrs)

11) Host Defense Centre Seminar, Montreal General Hospital, May 1994

"Cytokines in late phase reactions" (2 hrs)

12) Respiratory Rounds, Montreal General Hospital, June 1994

Quebec City, QC, February 1995

4) Centre de Pneumologie de l’Hopital Laval, Ste-Foy, QC, June 1995

“Modulation of cytokine expression by steroids in allergic diseases and asthma”

5) Regional Respiratory Rounds, McMaster University, Hamilton, ON, June 1995

“Cytokines and their receptors in asthma”

6) 49th Annual Scientific Meeting, Canadian Society of Otolaryngology, June 1995

“Eosinophil-associated cytokine receptors in chronic sinusitis”

7) Pulmonary Research Laboratory, The University of British Columbia, Vancouver, BC, August 1995

8) Research in Progress Seminars and the Asthma Centre Rounds, Toronto, ON,

November 1996

“Role of cytokine in the pathogenesis of allergic inflammation”; “Cytokines, asthma, and steroids”

9) Cytokines and Inflammation workshop, Montreal, February 1996

“New Techniques in Cytokine Biology”

10) Cytokines and Inflammation workshop, Montreal, February 1996

“Cytokine receptors in Asthma”

11) Inspiraplex: Airway Inflammation and Remodelling in Asthma Workshop, March 1996

“Cytokines and Asthma”

12) Inspiraplex: Airway Inflammation and Remodelling in Asthma Workshop, March 1996

“Lymphocytes”

13) Conference de Pharmacologie, Sherbrooke, Quebec, January 1997

“Role of IL-5 and Eotaxin in Eosinophil Accumulation and Activation in Allergic Inflammation”

14) Inspiraplex: Airway Epithelial Cell Workshop, January 1997 “Cytokines and Chemokines in Epithelial Cells”

15) Meakins-Christie 25th Anniversary Scientific Conference, Montreal, May 1997

“Cytokines and Cytokine Receptors in Asthma”

16) Schering Canada Inc.: Nasonex Canadian Investigators’ Meeting, Toronto, October 1997

“Effects of Mometasone on Nasal Mucosa on Patients with Perennial Rhinitis”

17) Chemokines, Eosinophils & Astma, Network Centre of Excellence Workshop, Merck Frosst Canada, February 1998

“Eosinophils in Asthma”

18) Rhinosinusitis Workshop, Ste-Adele, Quebec, March 1998

“Histopathology and Immunocytochemistry: Influence of Treatment”

19) Rhinosinusitis Workshop, Mont Ste-Anne, Quebec, April 1998

“Mechanisms of Inflammation in Chronic Sinusitis”

20) Ateliers en allergie, Lac Carling, Pine Hill, Quebec, November 1998

“Pathogens of allergy inflammation”

21) McGill University, Montreal, Quebec, November 1998

“Clinical Implications of Molecular Biology”

22) Merck Frosst Canada Inc., Montreal, Quebec, November 1998

“Remodelling-Related Airway Architectural Changes”

23) McGill University, Montreal General Hospital, Montreal, Quebec, February 1999

“Cytokines in Allergic Inflammation”

24) Schering Canada,, St-Sauveur, Quebec, February 1999

“Cytokines in Allergy of the Skin”

25) Rhinosinusitis Workshop, Mont Ste-Anne, Quebec, April 1999

“New Advances in the Pathogenesis of Chronic Sinusitis”

26) Quebec Thoracic Society Meeting, October 1999, Montreal, Quebec

P.T. Macklem Conference

27) McGill University, Department of Pathology, Montreal, Quebec November 1999

“Clinical Implications of Molecular Pathology”

28) Reseau Meeting, Quebec City, Quebec, March 2000

“Cytokines and transcription factors in asthma”

29) Univesity of Western Ontario, London, ON, October 2000

“The Role of the Small Airways in Asthma and other Respiratory Diseases: How important are they?

30) Allergy and Otolaryngology, Niagara-on-the-Lake, November 2000

“Molecular mechanism of sinonasal inflammation”

31) Schering Canada, Mont-Tremblant, Quebec, January 2001

“Cytokines, chemokines, transcription factors in asthma”

32) Challenging Airway Problems, Banff, Alberta, February 2001

“Pathophysiology of rhinitis and chronic sinusitis”

33) 3M Canada, Montreal, Quebec, February 2001

34) QVAR, Montreal, Quebec, March 2001

“Why should we treat small airways in asthma?”

35) McMaster University, Hamilton, Ontario, April 2001

36) Eosinophil 2001 International Symposium, Banff, Alberta, May 2001

“Role of IL-9 in regulating eosinophil function”

37) 3M - The Role of Small Airways in Asthma: New Concepts in Pathophysiology and Treatment”, Magog, Quebec, June 2001

“Pathology of Small Airways in Asthma”

38) University of Toronto, Joint Asthma/Respiratory Seminar

Toronto, Ontario, November 2001

“Recent Advances in the Pathogenesis of Asthma”

39) Hopital Hotel Dieu, University of Montreal

Montreal, Quebec, February 2002

“Recent Advances in the Pathogenesis of Asthma”

40) 3M Symposium on “Nouveautes dans le traitement de l’asthme et des MPOC”

Chateau Bromont, Magog, Quebec, April 2002

“Small Airways in Asthma - Does it matter?”

41) Merck Frosst Medical Advisory Meeting, Montreal, May 2002

“United Airway”

42) Upper Airway Meeting, Toronto, ON, November 2002

“The inflammatory cascade”

43) Canadian Society of Allergy and Clinical Immunology, Quebec City, November 2002

“Poster discussion symposium”

44) 2004 Wiselberg Seminar, Four Points Sheraton, Montreal, June 2004

“Pathogenesis of COPD”

45) Veterinary Comparative Respiratory Society Meeting, Old Montreal, Quebec, October 2004

“Lung injury and repair”

46) Pediatric Allergy-Immunology Retreat. McGill University Health Center, Montreal, October 2004

“Mechanisms of immunotherapy”

48) Innate Immunity: Basic Mechanisms and Role in Lung Disease Workshop, Meakins-Christie Laboratories, McGill University, Montreal, April 2007

“TLR 4 receptors in allergic and non-allergic inflammation”

49) Remodeling Workshop, Town Hall, Toronto (September 2007)

50) Sacre-Coeur Hospital, Montreal, Quebec, November 2007 – Graceway Pharmaceuticals

“What’s new in the pathology of asthma”

51) Jewish General Hospital, Montreal, Quebec, November 2007 – Graceway Pharmaceuticals

“What’s new in the pathogenesis of asthma”

52) Sherbrooke University, Sherbrooke, Quebec, November 2007 – Merck Frosst Canada

“Severe asthma remodeling”

International Meetings/Invited Speaker

1) INSERM, Cytokine Workshop, May 1994, Paris, France

"Cytokine producing cells"

2) Pasteur Institute, Lille, France, May 1994

"Cytokine and allergy"

3) American Academy of Allergy and Immunology, New York, February 1995

“Skin allergic inflammation: role of cytokines”

4) Asthma Conference, Washington University in St. Louis, St. Louis, MO, April 1995

“Cytokines and asthma”

5) Asthma Conference, Washington University in St. Louis, St. Louis, MO, April 1995

“Immunopathology of late airway responses”

6) Schering-Plough Research Institute, Kenilworth, NJ, May 1995

“Nasal allergy”

7) American Academy of Allergy Asthma & Immunology, March 1996

“Cytokines and Cytokine Receptors in Allergic Inflammation”

8) International Symposium on Eosinophils in Allergic Inflammation and Parasitic and Infectious Diseases, Rio de Janeiro, Brazil, June 1996

“IL-5 and IL5 Receptors in Asthma and Inflammation”

9) Interasma Society Meeting, Tokyo, Japan, October 23-November 5, 1996

“Pathogenesis of Asthma”

10) American Academy of Allergy Asthma & Immunology, San Francisco, USA, February 1997

“T Lymphocytes”

11) Schering-Plough Allergy Symposium on New Approaches in Rhinitis Therapy, Stockholm, Swedan, April 1997

“Long term Study with Mometasone Furoate Nasal Spray on the Nasal Mucosa”

12) Merck Frosst Annual Medical Advisory Council Meeting, Prague, Czech Republic, June 1997

“Cytokines - Mediators Interactions”

13) Targeting Drugs to the Lung workshop, London, England, June 1997

“Small Airway Inflammation in Asthma”

14) 3rd World Congress on Inflammation, Tokyo, Japan, November 16-20, 1997

“Airway Inflammation”

15) Taiwan Respiratory and Critical Care Meeting, Taipei, Taiwan, December 13-15, 1997

“Steroid, Asthma and Cytokines”

16) Taiwan Respiratory and Critical Care Meeting, Taipei, Taiwan, December 13-15, 1997

“Cytokines and Chemokines in the Pathogenesis of Asthma”

17) American Academy of Allergy, Asthma and Immunology, Washington, USA, March 13-18, 1998

“Role of T-cells in Allergy”

18) American Academy of Allergy, Asthma & Immunology, Washington, USA, March 13-18, 1998

“Pathogenesis of Severe Asthma”

19) American Thoracic Society, Chicago, IL, April 24-29, 1998

“Inflammatory Mechasims of Human Asthma”

20) Magainin Pharmaceuticals Inc., Plymouth Meeting, PA, August 24-25, 1998

“Cytokine and Cytokine Receptors in Asthma”

21) European Respiratory Society - Sputum Meeting, Geneva, Switzerland, September 17-19, 1998

“In Situ Hybridization and Cytokines in Induced Sputum of Asthmatics”

22) Osaka University, Osaka, Japan, October 5, 1998

“Role of Cytokines in Asthma”

23) Kyoto University, Kyoto, Japan, October 7, 1998

“Cytokine Receptors in Asthma”

24) American Thoracic Society Meeting, San Diego, CA, April 1999

“Airway Remodelling in Asthma”

25) Asthma 99 - Theory to Treatment, Honolulu, Hawaii, April 1999

“Collagen Deposition”

26) American Thoracic Society Meeting, San Diego, CA, April 1999

“Cytokines: Functional Consequences” , Facilitator

27) Johns Hopkins University, Baltimore, MD, May 1999

“Detection of Cytokines and Cytokine-Producing Cells in the Skin and Upper Airways during allergic Inflammatory Diseases”

28) Johns Hopkins University, Baltimore, MD, May 1999

“Molecular Methods in Biomedical Research”

29) Johns Hopkins University, Baltimore, MD, May 1999

“The Role of Cytokines, Chemokines and their Receptors in the Pathogenesis of Asthma”

30) National Heart and Lung Institute, London, UK, June 1999

“Molecular Immunopathology Techniques in Asthma”

31) Nasal & Pulmonary Drug Delivery Conference VI, Rome, Italy, September 1999

“Cytokines as a therapeutic target”

32) Airway Inflammation Asthma Meeting (ERS) Madrid, Spain, October 1999

“Invited Guest”

33) 49th Annual MTG. of the Japanese Society of Allergology, Hiroshima, Japan, October 1999

“Advances in the Pathophysiology of Bronchial Asthma”

34) United Arab of Emirates University, , United Arab of Emirates, November 1999

“The Role of Cytokines in Allergy and Asthma”

35) Autumn Immunology Conference, Chicago, IL, November 1999

“Contribution of T Cell-Derived Cytokines in Human Asthma”

36) The Anti-Asthmatic Actions and Selectivity of Inhaled Steroids in Asthma, Palm Beach, FL, December 1999

“Invited Guest”

37) Systemic Aspects of Allergic Inflammatory Disease, Orlando, FL, January 2000

“Recruitment to the Lungs in Humans”

38) Allergic Rhinitis: New Millenium Management, St. Thomas, US Virgin Isles, January 2000

“Cytokines and Chemokines in Allergic Inflammation, Rhinitis, Sinusitis”

39) IMASKO Meeting, Seville, Spain, January 2000

“Antiinflammatory effect of antibiotics”

40) INTERASTHMA Meeting, Tokyo, Japan, February 2000

“Airway Remodelling”

41) American Academy of Allergy, Asthma and Immunology mtg., San Diego, CA, March 2000

“T-cells in allergic inflammation”

42) Endobronchial Biopsies in Clinical Research: Task Force Mtg, London, UK, June 18-20, 2000

“In situ hybridization and new ways of visualization”

43) European Academy of Allergology and Clinical Immunology, Lisbon, Portugal, July 1-5, 2000

“Tissue Engineering”

44) British Society for Allergy and Clinical Immunology, Nottingham, UK, August 2-4, 2000

“Explant Models of Asthma”

45) 3M Canada, Kansas City, Kansas, September 2000

“The Mechanism of Steroid Resistance: Action of Steroids in Asthma”

46) 3M Canada, Kansas University, Kansas City, Kansas, September 2000

“The Role of Small Airways in Asthma and Inflammation”

47) QVAR Consultants’ Meeting, Indian Wells, CA, October 2000

“Invited Guest”

48) Aventis Pharma, Bermuda, January 2001

Invited Guest

49) The Small Airways in Asthma Roundtable, Forest Laboratories, Denver, Colorado, April 2001

“Invited Guest”

50) Iraqi Center for Heart Disease, Baghdad. Iraq, April 2001

“Cytokines, Inflammation and Remodeling of the airways and blood vessels”

51) Aventis Pharmaceuticals, Bridgewater, NJ, April 2001

“Cytokines and transcription factors in asthma”

52) American Thoracic Society Meeting, San Francisco, CA, May 2001

“Airway Smooth Muscle as a Pro-inflammatory cell”

53) Endobronchial Biopsies in Clinical Research: Understanding Pathogenesis and Effects of Treatment, Surrey, UK, June 2001

“Invited Guest”

54) MIT - Cambridge, Cambridge, MA, June 2001

“Recent Advances in the Pathogenesis of Asthma”

55) 19^th Annual Aspen Allergy Conference, Aspen, Colorado, July 2001

“Lessons from Airway Histopathology in Allergic and Non-Allergic Rhinosinusitis”

56) A.J. Kauvar Lectureship, National Jewish Medical and Research Center, August 2001

“Structural Cells of the Airways as a Site and Target for Inflammatory Mediators”

57) Sultan Qaboos University, College of Medicine, Dean’s Lecture, January 2002

“Pathogenesis and Treatment of Asthma”

58) Sultan Qaboos University, College of Medicine, January 2002

“Immunology of T cells in Allergy”

59) University of Chicago, February 2002

“Treatment options for persistent asthma”

60) University of Chicago, February 2002

“Singulair talk Title C”

61) Children’s Hospital Medical Center, Cincinnati, OH, February 2002 (Visiting Professor)

“Treatment options for persistent asthma”

62) American Thoracic Society Meeting, Atlanta, Georgia, USA, May 2002

“In situ hybridization”

63) American Thoracic Society Meeting, Atlanta, Georgia, USA, May 2002

“Characteristics of inflammation in asthma”

64) Roger S. Mitchell Lecturer, 45^th Annual Thomas L. Petty Aspen Lung Conference,

Aspen, USA, June 2002

“The Distal Lung in Asthma”

65) 5^th Annual Asthma Remodeling Research Meeting, Tokyo, Japan, July 2002

“Recent advances in the pathogenesis of asthma”

66) 5^th Annual Asthma Remodeling Research Meeting, Tokyo, Japan, July 2002

“Recent advances in the pathogenesis and treatment of obstructive airway disease”

67) 5^th Annual Asthma Remodeling Research Meeting, Tokyo, Japan, July 2002

“Airway remodeling in asthma”

68) 5^th Annual Asthma Remodeling Research Meeting, Tokyo, Japan, July 2002

“Cytokines in asthma and the role of anti-cytokine treatment”

69) 5^th Annual Asthma Remodeling Research Meeting, Tokyo, Japan, July 2002

“Pathogenesis of severe asthma”

70) Airway Remodeling Meeting, Keswick, Virginia, August 2002

“Pathological changes of airway remodeling”

71) JACI Editorial Board Meeting, Denver, Colorado, USA, September 2002

“Pathology”

72) EAACI Joint Session, Karlovy Vary, Prague, October 2002

“Recent advances in the pathogenesis of allergic inflammation”

73) National Training Program in Allergy and Asthma, Winnipeg, Manitoba, December 2002 (Visiting Professor)

“Eosinophils in allergic diseases”

74) National Training Program in Allergy and Asthma, Winnipeg, Manitoba, December 2002 (Visiting Professor)

“The development of asthma”, Public Lecture

75) Sultan Qaboos University, Oman, December 2002

“Invited External Examiner”

76) Advanced Medicine Symposium, Oman, January 2003

“ Physiopathology of asthma”

77) Advanced Medicine Symposium, Oman, January 2003

“New treatment options in asthma”

78) C.L. David comparative pathology seminar, Aventis Pharmaceuticals, Bridgewater, NJ, May 2003

“Pathophysiology of asthma”

79) Eosinophil Rising Meeting, Snowmass, Aspen, Colorado, June 2003

“Profibrotid cytokines, eosinophils and asthma”

80) World Allergy Organization Congress, Vancouver, BC, Canada, September 2003

“IL-9 and allergic inflammation”

81) World Allergy Organization Congress, Vancouver, BC, Canada, September 2003

“Pathophysiology of allergic rhinitis and asthma: Similarities and differences”

82) World Allergy Organization Congress, Vancouver, BC, Canada, September 2003

“Pathophysiological links between allergic rhinitis and asthma”

83) World Allergy Organization Congress, Breakfast Seminar, Vancouver, BC, Canada, September 2003

“Bronchitis and asthma”

84) European Respiratory Society Meeting, Vienna, Austria, September 2003

85) Saudi Thoracic Society Meeting, Saudi Arabia, February 2004

86) American Academy of Allergy, Asthma and Immunology, San Francisco, CA, March 2004

87) University of Vermont, Burlington, Vermont, USA, March 2004 (Visiting Professor)

“Mechanisms and pathology of asthma”

88) 5^th Annual Symposium on Specific Allergy, London, UK, April 2004

“Is the development of allergic inflammation reversible: con”

89) American Thoracic Society Meeting, Orlando, Florida, USA, May 2004

“Sampling the airways in patients with asthma and COPD”

90) Frontiers in Research and Clinical Management of Asthma and Allergy, Johns Hopkins Asthma and Allergy Center, May 2004

“Mechanisms of immunotherapy”

91) Frontiers in Research and Clinical Management of Asthma and Allergy, Johns Hopkins Asthma and Allergy Center, May 2004

“Mechanisms of CpG oligonucleotide: are the effects mediated through TLR-9 receptors?”

92) Sultan Qaboos University, Oman, Saudi Arabia, June 2004

Invited External Examiner

93) 19^th Conference of the Society of Drug Inhalation Therapy, June 2004

“Small airways inflammation in asthma: Pathology and therapeutical approaches by inhaled corticosteroids”

94) 12^th International Congress of Immunology, Montreal, Quebec, July 2004

“Airway inflammation in response to allergen”

95) 10^th International Sinusitis Meeting, New York, NY, September 2004

96) ACAAI Annual Meeting, Boston, USA, November 2004

“Local IgE synthesis in the production of respiratory tract disease”

97) American Academy of Allergy, Asthma, and Immunology, San Antonio, USA, March 2005

“Clinical Immunology”

98) Benjamin Burrows Lung Immunology Seminar Series, Tucson, AZ, April 2005

“Recent advances in asthma pathogenesis”

99) British Society for Allergy & Clinical Immunology (BSACI), Leicestershire, UK, July 2005

“Immunopathology of small airways disease in asthma”

100) Allergic Rhinitis Forum, Tokyo, Japan, August 2005

“Inflammatory cell”

101) Canadian Society of Allergy & Clinical Immunology (CSACI), Winnipeg, Canada, Sept. 2005

“Local IgE production”

102) 55^th Japanese Allergology Meeting, Morioka, Japan, October 2005

“Airway inflammation in asthma”

103) 55^th Japanese Allergology Meeting, Morioka, Japan, October 2005

“Management of small airway in asthma” (chair)

104) 5-Lipoxygenase Advisory Board Meeting, February 2006

“Airway remodelling”

105) Internal Medicine Update, Saudi Arabia, March 2006

“Bronchial asthma update”

106) Internal Medicine Update, Saudi Arabia, March 2006

“Research and epidemiology”

107) Internal Medicine Update, Saudi Arabia, March 2006

“How to write a scientific paper”

108) Internal Medicine Update, Saudi Arabia, March 2006

“A new era in COPD management”

109) AMGEN, March 2006

“Recent advances in the pathogenesis of asthma: Role of new cytokines”

110) 15^th Kamakura Conference, April 2006

“Immunomodulation of cytokine gene expression, potential tool for therapy in allergic rhinitis”

111) 15^th Kamakura Conference, April 2006

“Small airway inflammation in asthma: Therapeutic approaches by inhaled corticosteroids”

112) Intensive Course in Asthma, February 2007, Istanbul,Turkey

“Epidemiology of asthma: Possible causes of increased incidence”

113) Intensive Course in Asthma, February 2007, Istanbul, Turkey

“Pathology of asthma including inflammation and remodeling”

114) Intensive Course in Asthma, February 2007, Istanbul, Turkey

“Role of cytokines and chemokines in asthma”

115) Intensive Course in Asthma, February 2007, Istanbul, Turkey

“Severe asthma: A newentity or a failure to respond to treatment”

116) Intensive Course in Asthma, February 2007, Istanbul, Turkey

“Steroid-resistant asthma”

117) Intensive Course in Asthma, February 2007, Istanbul, Turkey

“United Airways: What is the link between asthma and rhinitis?”

118) Intensive Course in Asthma, February 2007, Istanbul, Turkey

“New therapies”

119) King Saudi University, Saudi Arabia, May 2007

“Application of molecular biology in human diseases”

120) King Saudi University, Saudi Arabia, May 2007

“Molecular biology and genetics of asthma and allergic diseases”

121) King Saudi University, Saudi Arabia, May 2007

“How to write and publish a scientific paper in high-impact journals”

122) American Thoracic Society Meeting, San Francisco, CA, USA, May 2007

“The pathology of small airway disease in asthma”

123) American Thoracic Society Meeting, San Francisco, CA, USA, May 2007

“The pathology of small airway disease in asthma”

124) Abbott Elderly Asthma Expert Meeting, American Thoracic Society Meeting, San Francisco, CA, USA, May 2007

“Small airways as a target for treatment of asthma in the elderly”

125) Damascus University, Syria, July 2007

“Recent advancements in the pathogenesis and therapeutics in asthma”

126) University of Leuven, Belgium, December 2007

“What’s new in the pathogenesis of asthma”

127) Merck Distinguished Speakers Series, Firestone Institute for Respiratory Health, January 2008

128) American Thoracic Society, Toronto, ON, Canada, May 2007

“Surrogate markers for animal and human remodeling status: Useful for COPD phenotyping”

129) American Thoracic Society, Toronto, ON, Canada, May 2007

“Can therapeutic targeting of cytokines control AHR?”

130) American Thoracic Society, Toronto, ON, Canada, May 2007

“IL-17 in disease: Lessons from atopic lung disease”

131) UAE Integrated Allergy Symposium, United Arab of Emirates, February 2008

“Recent advances in asthma”

132) Al-Ain International Immunology Meeting, United Arab of Emirates, March 2008

“New therapies in asthma”

LIST OF CURRENT FELLOWS/STUDENTS

Fellows: Students:

N. Takeda D. Prefontaine

A. Catalli J. Al Abri

O. Roshdy

J. Nadigel

W. Al Ramli

Technicians: Research Assistants Research Associates

E. Schotman S. Audusseau Alejandro Vasquez-Tello

M. Kafilmot S. Al Mot

P. Vallaincourt A. Mogas

Graduate Students who completed their degrees recently:

T. Naseer M. AlKerithy Dr. S. Sobol

S. Al Assaad M. Kontolemos

G. Shablovsky P. Christodoulopoulos

O. Ghaffar P. Fiset

L. Cameron S. Lajoie

T.E. Nutku P. Joubert

Clinical and Post-doctoral fellows who completed their fellowship :

Dr. E. Minshall Dr. D. Ihaku Dr. S. Letuve

Dr. S. Laberge Dr. H. Kondo Dr. C. Bergeron

Dr. S. Molet Dr. E. Wright Dr. I. Ito

Dr. B. Lamkhioued Dr. M. Toda Dr. K. Asai

Dr. Y. Nakamura Dr. S. Muro Dr. Y. Yamauchi

Dr. S. Miyata Dr. A. Shimbara Dr. S. Foley

Dr. K. Al Ghamdi Dr. A. Soussi-Gounni Dr. O. Al Dewachi

Dr. M. Tulic Dr. J. Shannon

Dr. M. Fukakusa Dr. H.P. Hauber

Y. Sumi P. Daigneault

ENT Resedents

Dr. S. Sobol

Dr. S. Fakhri

Dr. F. Saab

PUBLICATIONS (1987-2007)

Refereed papers, published or in press:

4. Q. Hamid, Varandell, N Ibrahim, P. Mingazzini, J.M. Polak. Extra-adrenal paragangliomas; An immunocytochemical and ultrastructural study. Cancer 60: 1776-1781, 1987.

5. Q. Hamid, B.J. Addis, D.R. Springall, N.B. Ibrahim, M.A. Ghatei, S.R. Bloom, J.M. Polak. Expression of the C-terminal peptide of human pro-bombesin in 361 lung endocrine tumours, a reliable marker and possible prognostic indicator for small cell carcinoma. Virchows Archiv. (A) 411: 185-192, 1987.

6. Q. Hamid, J. Wharton, G. Terenghi, C. Hassall, J. Aimi, K. Taylor, H. Nakazato, J. Dixon, G. Burnstock, J.M. Polak. Localization of aterial natiuretic peptide mRNA and immunoreactivity in rat heart and human atrial appendage. Proc. National Acad. Science USA 84: 6760-6764, 1987.

7. G.Terenghi, Q. Hamid,. J.M. Polak,, E. O'Brien, P Denny, S. Legon, J. Dixon, C.D. Minth, S.L. Palay, G. Yasargil, V. Chan-Palay. Localization of neuropeptide Y mRNA in neurons of human cerebral cortex by mean of in situ hybridization with complementary RNA probe. Proc. National Acad. Science USA 84: 7315-7318, 1987.

8. B. Addis, Q. Hamid, N. Ibrahim, M. Fahey, S.R. Bloom, J.M. Polak. Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung. J. Pathol. 153: 137-150, 1987.

9. P. Wilson, P. Barber, Q. Hamid, B. Power, A. Dhillon, J. Rode, I. Day, R. Thompson, J.M. Polak. The immunolocalization of protein gene product 9.5 using rabbit polyclonal and mouse monoclonal antibodies. Br. J. Exp. Pathol. 69: 91-104, 1988.

10. J.H. Steel, Q. Hamid, S. Van Noorden, P. Jones, P. Denny, J. Burrin, S. Legon, S.R. Bloom, J.M. Polak. Combined use of in situ hybridization and immunocytochemistry for the investigation of prolactin gene expression in immature, pubertal, pregnant, lactating and ovariectomise rats. Histochemistry 89: 75-80, 1988.

11. Q. Hamid, J. Rode, A. Flanagan, A.P. Dhillon, A.E. Bishop, M. Stratton, D.J. Evans, J.M. Polak. Endocrine differentiation in inflamed urinary bladder epithelium with metaplastic changes. Virchows Archiv. (A) 412: 267-272, 1988.

12. Q. Hamid, V. Chan-Palay, G. Yasargil,, J.M. Polak, S.L. Palay. Simultaneous demonstration of neuropeptide Y gene expression and peptide storage in single neurons of the human brain. Proc. National Acad. Science USA 85: 3213-3216, 1988.

13. Bhatnagar, D. Springall, M. Ghatei, P. Bernet, Q. Hamid, A. Giaid, N. Ibrahim. F. Cuttitta, E. Spindel, R. Penketh, C. Rodek, S.R. Bloom, J.M. Polak. Localization of mRNA and co-expression and molecular forms of GRP products in endocrine cells of fetal human lung. Histochemistry 90: 299-307, 1988.

14. P. Mulderry, M. Ghadei, R. Spokes, P. Jones, Q. Hamid, A. Pierson, S. Kanes, S. Amara, J. Burrin, S. Legon, J.M. Polak, S.R. Bloom. Differential expression of "-CGRP and $-CGRP by primary sensory neurons and enteric autonomic neurons of the rat. Neuroscience 25: 195-205, 1988.

15. S. Gibson, J.M. Polak, A. Giaid, Q. Hamid, S. Kar, P. Jones, P. Denny, S. Legon, S. Amara, S.R. Bloom, R. Penketh, C. Rodek, N. Ibrahim, A. Dawson. Calcitonin gene related peptide mRNA is expressed in sensory neurons of the dorsal root ganglia and also in spinal motorneurons in man and rat. Neuroscience Letters 91: 283-288, 1988.

16. D.R. Springall, M, Bhatnagar, J. Wharton, Q. Hamid, S. Gulbenkian, M. Hedges, L. Meleagros, S.R. Bloom, J.M. Polak. Expression of the atrial natriuetic peptide gene in the cardiac muscle of the rat extrapulmonary and intrapulmonary veins. Thorax 43: 44-52, 1988.

17. A.E. Bishop, D. Bretherton-Watt, Q. Hamid, M. Fahey, N. Shepherd, K. Valentino, K. Tatemoto, M. Ghatei, S.R. Bloom, J.M. Polak. The occurrence of pancrea to statin in tumours of the diffuse neuroendocrine system. Molecular and Cellular Probes 2: 225-235, 1988.

18. P. Denny, Q. Hamid, J.E. Krause, J.M. Polak. Oligo-riboprobes, tools for in situ hybridization. Histochemistry 89: 481-483, 1989.

19. Q. Hamid, A.A. Quaba, A.E. Bishop, D.R. Springall, C. Adams, A. Al Nafussi, P.J. Marangos, E. Ginns, J.M. Polak. Neuron-specific enolase and its mRNA are highly expressed in large congenital nevi. A Study Using Immunocytochemistry, Biochemical Assay and In Situ hybridization. J. Molecul. Neuroscience 1: 85-91, 1989.

20. J.M. Polak, Q. Hamid, D.R. Springall, F. Cuttitta, E. Spindle, M.A. Ghatei, S.R. Bloom. Localization of bombesin like peptides in tumours. Annals of the New York Acad. of Science 547: 322-335, 1988.

21. Q. Hamid, A.E. Bishop, D. Springall, C. Adams, A. Giaid, P. Denny, M. Ghatei, S. Legon, F. Cuttitta, J. Rode, E. Spindel, S.R. Bloom, J.M. Polak. Detection of human Probombesin mRNA in neuroendocrine (Small Cell) carcinoma of the lung. In Situ Hybridization with cRNA Probe. Cancer 63: 266-271, 1989.

22. A.E. Bishop, Q. Hamid, C. Adams, D. Bretherton-Watt, P. Jones, P. Denny, G. Stamp, R. Hurt, L. Grimilius, A. Harmar, K. Valentino, B. Cedermark, S. Legon, M Ghatei, S.R. Bloom, J.M. Polak. Expression of tachykinins by ileal and lung carcinoid tumours assessed by combined in situ hybridization, immunocytochemistry and radioimmunoassay. Cancer 63: 1129-1137, 1989.

23. A. Giaid, Q. Hamid, C. Adams, G. Trenghi, J.M. Polak. Non-isotopic RNA probes; Comparison between different labels and detection systems. Histochemistry 93: 191-196, 1989.

24. K. Sekiya, M. Chatei, Q. Hamid, J.M. Polak, S.R. Bloom. Production of GAWK Chromogranin-B 420-493)-like immunoreactivity by endocrine tumours and its possible diagnostic value. J. Clin. Invest. 83: 1834-1842, 1989.

25. A. Giaid, Q. Hamid, D. Springall, M. Yanagisawa, O Shinmi, T. Sawamura, T. Masaki, S. Kimura, B. Corrin, J. Polak. Detection of endothelin immunoreactivity and mRNA in pulmonary tumours. J. Pathology 1990; 162: 15-22

26. Q. Hamid, B. Corrin, A. Dewar, H. Hoefler, M.N. Sheppard. Expression of gastrin releasing peptide (human bombesin) gene in large cells undifferentiated carcinoma of the lung. J. Pathol. 161: 145-151, 1990.

27. M. Desperbasques, A. Dhillon, Q. Hamid. Epithelial changes following bone marrow transplantation: cytological atypia and epithelial endocrine cells. APMIS 99: 557-566, 1991.

28. M. Roncalli, D. Springall, I. Varandell, V. Gaitonde, Q. Hamid, N. Ibrahim, L. Grimelius, E. Wilander, J.M. Polak, G. Coggi. Oncoprotein immunoreactivity in human endocrine tumours. J. Pathol. 163: 117-127, 1991

29. A. Giaid, J. Polak, Q. Hamid, G. Moscoso, D. Springall. The distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung. Am. J. Respir. Cell Mol. Biol. 4: 50-58, 1991.

30. A.B. Kay, S. Ying, V. Varney, S.R. Durham, R. Moqbel, A. Wardlaw, Q. Hamid. Messenger RNA expression of the cytokine gene cluster, IL-3, IL-4, IL-5 and GM-CSF in allergen-induced late-phase cutaneous reactions in atopic subjects. J. Exp. Med. 173: 775-778, 1991.

31. Q. Hamid, J. Mak, M.N. Sheppard, B. Corrin, J. Venter, P.J. Barnes. Localization of beta-2 adrenoceptor mRNA in human and rat lung using in situ hybridization: correlation with receptor autoradiography. Europe J. of Pharmacology, Molecular Biology Section 206: 133-138, 1991.

32. Q. Hamid, B. Corrin, M.N. Sheppard, J.M. Polak. Expression of chromogranin A mRNA in small cell carcinoma of the lung. J. Pathol. 163: 293-297, 1991.

33. Q. Hamid, M. Azzawi, S. Ying, R. Moqbel, A. Wardlaw, C. Corrigan, B. Bradley, S.R. Durham, J. Collin, P. Jeffery, D. Quint, A.B. Kay. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. 87: 1541-1546, 1991.

34. Q. Hamid, M. Belvisi, C. David, Stretton, J. Rode, A. Harmar, P.J. Barnes. Localization of beta preprotachykinin mRNA in nodose ganglion. Neuropeptide 20: 145-150, 1991.

35. Q. Hamid, M. Azzawi, S.R. Durham, A.B. Kay. Interleukin-5 mRNA in mucosal bronchial biopsies from asthmatic subjects. Int. Arch. Allergy Appl. Immunol. 94: 169-170, 1991. (proceeding).

36. S. Ying, D. Robenson, R. Moqbel S.R. Durham, A.B. Kay, Q. Hamid. TNF-alpha mRNA expression in allergic inflammation. Clin. Exp. Allergy 21: 745-750, 1991.

37. R. Moqbel, Q. Hamid, S. Ying, A. Wardlaw, A.B. Kay. Expression of mRNA and immunoreactivity for the GM-CSF in activated human eosinophils. J. Exp. Med. 174: 749-752, 1991.

38. M. Sheppard, Q. Hamid, J.M. Polak. Immunohistology of lung tumours. Diagnostic Oncology 1: 252-261, 1991

39. A. Tsicopoulos, Q. Hamid, Varny, S. Ying, R. Moqbel, S.R. Durham, A.B. Kay. Preferential mRNA expression of Th-1 type cells (IFN gamma+, IL-2+) in classical delayed-typed (tuberculin) hypersensitivity reactions in human skin. J. Immonol. 148: 2058-2061, 1992.

40. D. Robinson, Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. Bentley, S.R. Durham, A.B. Kay. Predominant TH2-type bronchoalveolar T-lymphocytes population in atopic asthma. New. Eng. J. Med. 326: 298-304, 1992.

41. S. Durham, S. Ying, V. Varney, M. Jacobson, A.B. Kay, Q. Hamid. Cytokine messenger mRNA expression for IL-3, IL-4, IL-5 and granulocyte/macrophage -colony-stimulating factor in the nasal mucosa after local allergen provocation: Relationship to tissue eosinophilia. J. Immunol. 148: 2390-2394, 1992.

42. Q. Hamid, J Barkans, D. Robinson, S. Durham, A.B. Kay. Co- expression of CD25 and CD3 in atopic allergy and asthma. Immunology 75: 659-663, 1992.

43. O. Cromwell, Q. Hamid, C. Corrigan, J. Barkans, P. Colllins, A.B. Kay. Expression and generation of IL-8, IL-6 and GMCSF by bronchial epithelial cells and enhancement by IL-1 beta and TNF- alpha. Immunology 77: 330-337, 1992.

44. Q. Hamid, J. Barkans, Q. Meng, J. Abrams, A.B. Kay, R. Moqbel. Human eosinophils synthesize and secrete interleukin-6, in vitro. Blood 80: 1496-1501, 1993.

45. A.M. Bentley, Q. Meng, D.S. Robinson, Q. Hamid, A.B. Kay, S.R. Durham. Increases in activated T lymphocytes, eosinophils and cytokine messenger RNA expression for IL-5 and GM-CSF in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. Am. J. Resp. Cell Mol. Biol. 8: 35-42, 1993.

46. A. Giaid, R. Michel, D. Stewart, M. Sheppard, B. Corrin, Q. Hamid. Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis. The Lancet 341: 1550-1554, 1993.

47. S. Salim, C. Milroy, J. Rode, B. Corrin, Q. Hamid. Immunocytochemical characterisation of neuroendocrine tumours of the larynx. Histopathology 23: 69-73, 1993.

48. D.S. Robinson, Q. Hamid, M. Jacobson, S. Ying, A.B. Kay, S.R. Durham. Evidence for Th₂-type T helper cell control of allergic disease in vivo. Springer Semin. Immunopathol. 15: 17-27, 1993.

49. A.B. Kay, Q. Hamid, D.S. Robinson, A.M. Bentley, A. Tsicopoulos, Sun Ying, R. Moqbel, C.J. Corrigan, S.R. Durham. T Lymphocyte/eosinophil interactions in atopic asthma: critical role for interleukin-5. Progress in Immunology, 403-410, 1993.

50. A.B. Kay, S.R. Durham, R. Moqbel, Q. Hamid. In situ hybridization in the study of allergic disease. Allergy Clin. Immunol. 5(1): 15-18, 1993.

51. D.L. Hamilos, D.Y.M. Leung, R. Wood, A. Meyers, J.K. Stephens, J. Barkans, L. Cunningham, D.K. Bean, A.B. Kay, Q. Hamid. Chronic hyperplastic sinusitis: association of tissue eosinophilia with mRNA expression of GM-CSF and IL-3. J. Allergy Clin. Immunol. 92: 39-48, 1993.

52. D.S. Robinson, Q. Hamid, A. Bentley, S. Yeng, A.B. Kay, S.R. Durham. Activation of CD4⁺ T cells, increased Th2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J. Allergy Clin. Immunol. 92: 313-324, 1993.

53. S. Ying, K. Barkans, K. Masuyama, M.R. Jacobson, S. Rak, O. Lowhagen, R. Moqbel, S.R. Durham, A.B. Kay, Q. Hamid. T cells, mast cells and eosinophils are principal sources of interleukin-5 mRNA in allergen-induced allergic rhinitis. Am. J. Resp. Cell Mol. Biol. 9: 356-360, 1993.

54. D.S. Robinson, Q. Hamid, S. Ying, A.M. Bentley, B. Assoufi, J. North, Q. Meng, S.R. Durham, A.B. Kay. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell IL-4, IL-5 and IFN-gamma cytokine gene expression. Am. Rev. Respir. Dis. 148: 401-406, 1993.

55. D.S. Robinson, S. Ying, A.M. Bentley, Q. Meng, J. North, S.R. Durham, A.B. Kay, Q. Hamid. Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J. Allergy Clin. Immunol. 92: 397-403, 1993.

56. V.A. Varney, Q. Hamid, M. Gaga, S. Ying, M. Jacobson, A.J. Frew, A.B. Kay, S.R. Durham. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous response. J. Clin. Invest. 92: 644-651, 1993.

57. Q. Hamid, Dr. Springall, V. Riveros-Moreno, P. Chanez, P. Howarth, A. Redington, J. Bousquet, P. Godard, S. Holgate, J.M. Polak. Induction of nitric oxide synthase in asthma. The Lancet 342: 1510-1513, 1993.

58. D.S. Robinson, S. Ying, I.K. Taylor, A. Wangoo, D.M. Mitchell, A.B. Kay, Q. Hamid, R.J. Shaw. Evidence for a Th1-like bronchoalveolar T cell subset and predominance of IFN-gamma gene activation in pulmonary tuberculosis. Am. J. Respir. Crit. Care Med. 149: 989-993, 1994.

59. A. Tsicopoulos, Q. Hamid, A. Haczku, M.R. Jacobson, S.R. Durham, J. North, J. Barkans, C.J. Corrigan, Meng Qiu, R. Moqbel, A.B. Kay. Kinetics of cell infiltration and cytokine messenger RNA expression after intradermal challenge with allergen and tuberculin in the same atopic individuals. J. Allergy Clin. Immunol. 94: 764-772, 1994.

60. K. Masuyama, M.R. Jacobson, S. Rak, Q. Meng, R.M. Sudderick, A.B. Kay, O. Lowhagen, Q. Hamid, S.R. Durham. Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis. Immunology 82: 192-199, 1994.

61. S. Rak, M.R. Jacobson, R.M. Sudderick, K. Masuyama, A.B. Kay, Q. Hamid, O. Lowhagen, S.R. Durham. Influence of prolonged treatment with topical corticosteroid (fluticasone propionate) on early and late-phase nasal responses and cellular infiltration in the nasal mucosa after allergen challenge. Clin. Exp. Allergy 24: 930-939, 1994.

62. Q. Hamid, M. Boguniewicz, D.Y.M. Leung. Differential in situ cytokine gene expression in acute vs chronic atopic dermatitis. J. Clin. Invest. 94: 870-876, 1994.

63. S. Ying, S.R. Durham, M.R. Jacobson, S. Rak, K. Masuyama, O. Lowhagen, A.B. Kay, Q. Hamid. T lymphocytes and mast cells express messenger RNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis. Immunology 82: 200-206, 1994.

64. P. Jeannin, Y. Delneste, P. Gosset, P. Lassalle, Q. Hamid, J. Pestel, A. Tsicopoulos, A. Tonnel. Histamine induces IL-8 secretion by endothelial cells. Blood 84(7): 2229-2233, 1994.

65. Q. Hamid, S. Ying, A.B. Kay. Cytokine producing cells: Phenotype of cells expressing cytokine mRNA in human tissue. Atelier de formation NO 63, INSERM, Les cellules productrices de cytokines. Le vesinet, Atelier 63: 99-120, 1994.

66. D.Y.M. Leung, R.J. Martin, S.J. Szefler, E.R. Sher, S. Ying, A.B. Kay, Q. Hamid. Dysregulation of Interleukin-4, Interleukin-5, and Interferon-( gene expression in steroid-resistant asthma. J. Exp. Med. 181: 33-40, 1995.

67. D.L. Bratton, Q. Hamid, M. Boguniewicz, D.E. Doherty, J.M. Kailey, D.Y.M. Leung. Granulocyte macrophage-colony stimulating factor contributes to enhanced monocyte survival in chronic atopic dermatitis. J. Clin Invest. 95: 211-218, 1995.

68. S. Ying, S.R. Durham, Q. Hamid, A.B. Kay. Phenotype of cells expressing mRNA for Th2-type (interleukin-4 and interleukin-5) and Th1-type (interleukin-2 and interferon-gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatics and normal control subjects. Am. J. Resp. Cell. Mol. Biol. 12: 477-487, 1995.

69. C.J. Corrigan, Q. Hamid, J. North, J. Barkans, R. Moqbel, S. Durham, A.B. Kay. Peripheral blood CD4 but not CD8 T lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy. Am. J. Resp. Cell. Mol. Biol. 12: 567-578, 1995.

70. K. Arsalane, P. Gosset, D. Vanhee, C. Voisin, Q. Hamid, A-B. Tonnel, B. Wallert. Ozone stimulates synthesis of inflammatory cytokines by alveolar macrophages in vitro. Am. J. Respir. Cell Mol. Biol. 13: 60-68, 1995.

71. A. Watanabe, H. Mishima, P. Renzi, L.J. Xu, Q. Hamid, J. Martin. Transfer of Allergic Airway Responses with Antigen-Primed CD4+ but not CD8+ T Cells in Brown Norway Rats. J. Clin. Invest. 96: 1303-1310, 1995.

72. D.L. Hamilos, D.Y.M. Leung, R. Wood, L. Cunningham, D.K. Bean, Z. Yasruel, E. Schotman, Q. Hamid. Evidence for distinct cytokine expression in allergic versus non-allergic chronic sinusitis. Am. J. Allergy Clin. Immunol. 96:537-544, 1995

73. A.M. Bentley, Q. Hamid, D.S. Robinson, E. Schotman, M. Qiu, B. Assoufi, A.B. Kay, S.R. Durham. Prednisolone treatment in asthma: Reduction in the numbers of eosinophils, T cells, Tryptase-only positive mast cells and modulation of IL-4, IL-5 and interferon-gamma cytokine gene expression within the bronchial mucosa. Am. J. Respir. Crit. Care Med. 153: 551-556, 1996.

74. D. Robinson, A. Tsicopoulos, Q. Meng, S. Durham, A.B. Kay and Q. Hamid. Increased interleukin-10 messenger RNA expression in atopic allergy and asthma. Am. J. Respir. Cell Mol. Biol. 14: 113-117, 1996.

75. C. Duez, A.Tsicopoulos, A. Janin, I.Tillie-Leblond, G. Thyphronitis, P. Marquilles, Q. Hamid, B. Wallaert, A.B.Tonnel, J. Pestel. An in vivo model of allergic inflammation: pulmonary human cell infiltrate in allergen-challenged allergic Hu-SCID mice. Eur. J. Immunol. 26: 1088-1093, 1996.

76. H. Akoum, A. Tsicopoulos, H. Vorng, B. Wallaert, J.P. Dessaint, M. Joseph, Q. Hamid, A. B. Tonnel. Venom immunotherapy modulates IL-4 and IFN-( mRNA expression of peripheral T lymphocytes. Immunology 87: 593-598, 1996.

77. S.R. Durham, Sun Ying, V.A. Varney, M.R. Jacobson, R.M. Sudderick, I.S. Mackay, A.B. Kay, Q. Hamid. Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma. J. Allergy Clin. Immuno. 97: 1356-1365, 1996.

78. Q. Hamid, T. Naseer, E. Minshall, Y.L. Song, M. Boguniewicz, D.Y.M. Leung. In vivo expression of interleukin-12 and interleukin-13 in atopic dermatitis. J. Allergy Clin. Immunol. 98: 225-231, 1996. (MT-13273)

79. A.T.C. Kotsimbos, P. Ernst, and Q. Hamid. IL-13 and IL-4 are co-expressed in atopic asthma. Proceed. Assoc. Am. Physic.108: 368-373, 1996.

80. P.M.Renzi, S. Al Assaad, J.P. Yang, Z. Yasruel,, Q. Hamid. Cytokine expression in the presence or absence of late airway responses after antigen challenge of sensitized rats. Am. J. Respir. Cell Mol. Biol. 15: 367-373, 1996. (MT-13273)

81. D.L. Hamilos, D.Y.M. Leung, R. Wood, L. Cunningham, D.K. Bean, S. Ying, E. Schotman, Q. Hamid. Eosinophil infiltration in nonallergic chronic hyperplastic sinusitis with nasal polyposis (CHS/NP) is associated with endothelial VCAM-1 upregulation and expression of TNF-". Am. J. Respir. Cell Mol. Biol. 15: 443-450, 1996.

82. A.T.C. Kotsimbos, K.A. Ghamdi, P. Small, S. Frenkiel, Q.A. Hamid. Upregulation of Th-2 cytokine receptors in atopy and non-atopy associated chronic sinusitis. J. Otolaryn. 25: 317-321, 1996.

83. E.A. Garcia-Zepeda, C. Combadiere, M.E. Rothenberg, M.N. Sarafi, F. Lavigne, Q. Hamid, P.M. Murphy, A.D Luster. Human monocyte chemoattractant protein (MCP)-4: a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and non-allergic inflammation that signals through the CC chemokine receptors CKR-2 and -3. J. Immunol. 157: 5613-5626, 1996.

84. D.H. Eidelman, E. Minshall, R.J. Dandurand, E. Schotman, Y.L. Song, Z. Yasruel, R. Moqbel, Q. Hamid. Evidence for major basic protein immunoreactivity and IL-5 gene activation during the late phase response in explanted airways. Am. J. Resp. Cell Mol. Biol. 15: 582-9, 1996. (MT-13273)

85. K. Al Ghamdi, O. Ghaffar, P. Small, S. Frenkiel, and Q.A. Hamid. IL-4 and IL-13 expression in chronic sinusitis. Relationship with cellular infiltrate and the effect of topical corticosteroid treatment. J. Otolaryngol. 26:160-166, 1997.

86. T. Naseer, E. Minshall, D.Y Leung, S. Laberge, P. Ernst, R.J. Martin, Q. Hamid. Expression of interleukin-12 and interleukin-13 mRNA in asthma and their modulation in response to steroid therapy. Am.J.Respir.Crit. Care Med. 155(3): 845-51, 1997. (MT-13273)

87. R. Sehmi, L.J. Wood, R. Watson, R. Foley, Q. Hamid, P.M. O’Byrne, J.A. Denburg. Allergen-induced increases in IL-5 receptor "-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. J. Clin. Invest. 100: 2466-2475, 1997.

88. R. Taha, T.C. Kotsimbos, Y.L. Song, R. Menzies, Q.A. Hamid. IFN-( and IL-12 mRNA are increased in active compared with inactive pulmonary tuberculosis. Am. J. Respir. Crit. Care Med. 155: 1135-9, 1997.

89. Q. Hamid, E. Schotman, M.R. Jacobson, S. M. Walker, S.R. Durham. Increases in Interleukin-12 (IL-12) messenger RNA+ (mRNA+) cells accompany inhibition of allergen induced late skin responses following successful grass pollen immunotherapy. J. Allergy Clin. Immunol. 99: 254-60, 1997.

90. K. Rajakulasingam, Q. Hamid, F.O’Brien, E. Schotman, P.J. Jose, T.J. Williams, M. Jacobson, J. Barkans, S.R. Durham. RANTES in human allergen-induced rhinitis: cellular source and relation to tissue eosinophilia. Am. J. Respir. Crit. Care Med. 155: 696-703, 1997.

91. A. Watanabe, H. Mishima, A.T.C. Kotsimbos, P.M. Renzi, J.G. Martin, Q. Hamid. Adoptively transferred late allergic airway responses are associated with Th2 type cytokines in the rat. Am. J. Respir.Cell. & Mol. Bio. 16:69-74, 1997. (MT-13273)

92. Z. Yasruel, M. Humbert, A.T.C. Kotsimbos, Y. Ploysongsang, E. Minshall, S. Durham, R. Pfister, G. Menz, J Tavernier, A.B. Kay, Q. Hamid. Membrane-bound and soluble interleukin-5 alpha receptor mRNA in the bronchial mucosa of atopic and non-atopic asthmatics. Am. J. Respir. Crit. Care Med. 155;1413-1418, 1997. (MT-13273)

93. A. T. C. Kotsimbos, M. Humbert, E. Minshall, S. Durham, R. Pfister, G. Menz, J. Tavernier, A.B. Kay, Q. Hamid. Upregulation of " GM-CSF-receptors in non-atopic but not in atopic asthma. J. Allergy Clin. Immunol. 99:666-72, 1997. (MT-13273)

94. O. Ghaffar, S. Laberge, M. Jacobson, O. Lowhagen, S.D. Durham, Q.A. Hamid. IL-13 mRNA and immunoreactivity in allergen-induced rhinitis: comparison with IL-4 expression and modulation by topic glucocorticoid therapy. Am. J. Respir. Cell Mol. Biol. 17:17-24, 1997. (MT-13273)

95. P.M. Renzi, N. Sebastiao, A.Giaid, Q. Hamid. Inducible nitric oxide synthase mRNA and immunoreactivity in the lungs of rats after antigen challenge Am.J.Resp.Cell Mol.Biol. 17:36-40, 1997.

96. Q.A. Hamid, Y.L. Song, T.C. Kotsimbos, E. Minshall, T.R. Bai, R.G. Hegele, J.C.Hogg. Inflammation of small airways in asthma. J.Allergy Clin.Immunol.100:44-51,1997.(MT-13273)

97. S. Laberge, P. Ernst, O. Ghaffar, W.W. Cruikshank, H. Kornfeld, DM. Center, Q.A. Hamid. Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma. Am. J. Respir. Cell Mol. Biol. 17:193-202, 1997

98. V. Gemou-Engesaeth, A. Bush, A.B. Kay, Q. Hamid, C.J. Corrigan. Inhaled glucocorticoid therapy of childhood asthma is associated with reduced peripheral blood T-cell activation and “Th-2-Type” cytokine mRNA expression. Pediatrics. 99:695-703, 1997.

99. S. Laberge, S. Durham, O. Ghaffar, S. Rak, D.M. Center, M. Jacobson, Q. Hamid, Expression IL-16 in allergic-induced late phase nasal responses and relation to topical glucocorticosteroid treatment. J. Allergy Clin. Immunol. 100: 569-574, 1997.

100. E. Minshall, D. Leung, Y.L. Song, L. Cameron, Q.A. Hamid. Eosinophil-associated TGF-$ mRNA expression and airways fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 17: 326-333, 1997. (MT-13273)

101. B. Lamkhioued, P.M. Renzi, S. Abi-Younes, E.A. Garcia-Zepada, A.D. Luster, Q. Hamid. Increased expression of eotaxin in BAL and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J. Immunology. 159:4593-4601, 1997. (MT-13273)

102. D. Leung, Q. Hamid, A. Vottero, S.J. Szefler, w. Surs, E. Minshall, G.P. Chrousos, D. Klemm. Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor. J. Exp. Med. 186: 1567-1574, 1997.

103. E. Minshall, A. Tsicopoulos, Z. Yasruel, B. Wallaert, H. Akoum, H. Vorng, A.B. Tonnel, Q. Hamid. Cytokine mRNA gene expression in active and non-activity pulmonary sarcoidosis. Eur. Resp. J. 10:2034-39, 1997. (MT-13273)

104. E. Minshall, L. Cameron, F. Lavigne, D.Y.M. Leung, D. Hamilos, M. Rothenberg, A. Luster, Q. Hamid. Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. Am. J. Respir. Cell Mol. Biol. 17: 683-690, 1997. (MT-13273)

105. S.R. Durham, H. J.Gould, C.P. Thienes, M.R. Jacobson, K. Masuyama, S. Rak, O. Lowhagen, E. Schotman, L. Cameron, Q.A. Hamid. Expression of , germ-line gene transcripts and mRNA of the , heavy chain of IgE in nasal B cells and the effects of topical corticosteroid. Eur. J. Immunol. 27: 2899-2906, 1997.

106. A.T.C. Kotsimbos, Q. Hamid. IL-5 and IL-5 Receptor in Asthma. Proceedings in Mem. Inst. Oswaldo Cruz, Rio de Janeiro. 92(Suppl. II): 75-91, 1997. (MT-13273)

107. E. D. Wright, S. Frenkiel, K. Al-Ghamdi, O. Ghaffar, P. Small, T. Troutt, J. Tavernier, Q. Hamid. IL-4, IL-5, and granulocytemacrophage colony-stimulating factor receptor expression in chronic sinusitis and response to topical steroids. Otolaryngol. Head, Neck Surg. 118: 490, 1998.

108. E. Minshall, J.C. Hogg, Q. Hamid. Cytokine mRNA expression in asthma is not restricted to the large airways. J. Allergy Clin. Immun. 101: 386-390, 1998. (MT-13273)

109. L.A. Cameron, S.R. Durham, M.D. Mikila, R. Jacobson, K. Masuyama, S. Juliusson, H.J. Gould, O. Lowhagen, E.M. Minshall, Q.A. Hamid. Expression of IL-4 Cg and Ig RNA in the nasal mucosa of patients with seasonal rhinitis: effect of topical corticosteroids. J. Allergy Clin. Immunol. 101: 330-336, 1998.

110. O. Ghaffar, S. Durham, K. Al-Ghamdi, E. Wright, P. Small, S. Frankiel, H.J. Gould, Q. Hamid. Expression of IgE heavy chain transcripts in the sinus mucosa of atopic and non-atopic patients with chronic sinusitis. Am. J. Res. Cell. Mol. Biol. 18: 706-711, 1998.

111. Q.A. Hamid.. Cytokines in immunologically mediated lung diseases. The Allergy in Practice. 18: 65-69, 1998.

112. A. Tsicopoulos, J. Pestel, O. Fahy, H. Vorng, F. Vandenbusche, H. Porte, L. Eraldi, A. Wurtz, H. Akoum, Q. Hamid, B. Wallaert, A.B. Tonnel. Tuberculin-induced delayed-type hypersensitivity reaction in a model of hu-PBMC-SCID mice grafted with autologous skin. Am. J. Pathol. 152: 1681-1688, 1998.

113. R.A. Taha, D.Y.M. Leung, O. Ghaffar, M.Boguniewicz, Q. Hamid. In vivo expression of cytokine receptor mRNA in atopic dermatitis. J. Allergy Clin. Immunol. 102: 245-50, 1998.

114. E. Minshall, O. Ghaffar, L. Cameron, F. O’Brien, H. Quinn, J. Jones, R. Davies, V.J. Lund, I.S. Mackay, K. Nolop, B.N. Lutsky, S. Durham, Q. Hamid. Assessment by nasal biopsy of log term Mometasone furoate aqueous nasal spray (Nasonex) in the treatment of perennial rhinitis. Otolaryngol. Head, Neck Surg. 11: 648-54, 1998.

115. E.M. Minshall, R. J. Dandurand, Q. Hamid, D. H. Eidelman. Local cytokine mRNA expression and in vitro allergic late phase responses in Brown-Norway rats. Eur.Res. J. 11: 630-635, 1998. (MT-13273)

116. E.M. Minshall, R. Schleimer, L. Cameron, M. Minicozzi, R.E. Egan, J-C Gutierrez-Ramos, D. H. Eidelman and Q. Hamid. IL-5 expression in the bone marrow of sensitized balb/c mice following allergen challenge: evidence for T cell involvement. Am. J. Respir. Crit. Care Med. 158: 951-957, 1998. (MT-13273)

117. K. Sigman, F. Ghibu, W. Sommerville, B.J. Toledano, Y. Bastien, L. Cameron, Q.A. Hamid, B. Mazer. Intravenous immunoglobulin inhibits IgE production in human B lymphocytes. J. Allergy Clin. Immunol., 102: 421-427, 1998.

118. N.B. Sweezey, S. Ghibu, S. Gagnon, E. Schotman, Q.A. Hamid. Glucocorticoid receptor mRNA and protein in fetal rat lung in vivo: Modulation by glucocorticoid and and androgen. Am. J. Physiol. (Lung Cell Mol. Physiol.) 19: L103-L109, 1998.

119. E. Wright, S. Frenkiel, P. Small, P. Christodoulopoulos, Q. Hamid. Th-2 type cytokine receptors in allergic rhinitis and in response to topical steroids. Otolaryng. Head & Neck Surg. 118: 804, 1998.

120. E. Wright, S. Frenkiel, O. Ghaffar, K. Al-Ghamdi, A. Luster, D. Miotto, Q. Hamid. Monocyte chemotactic protein expression in allergy and non-allergy-associated chronic sinusitis. J. Otolaryngol. 27:281-287, 1998.

121. K. Masuyama, S.J., Till, M.R. Jacobson, A. Kamil, L. Cameron, S. Juliusson, O. Lowhagen, A.B. Kay, Q.A. Hamid, S.R. Durham. Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: Effect of topical corticosteroids. J. Allergy Clin Immunol. 102: 610-617, 1998.

122. S. Laberge, O. Ghaffar, M. Boguniewicz, D.M. Center, D.Y.M. Leung, Q. Hamid. Association of increased CD4+ T-cell infiltration with increased IL-16 gene expression in atopic dermatitis. J. Allergy Clin. Immunol. 102: 645-650, 1998.

123. T.C. Kotsimbos, O. Ghaffar, E.M. Minshall, M. Humbert, S.R. Durham, R. Pfister, G. Menz, A.B. Kay, Q.A. Hamid. Expression of IL-4 receptor "-subunit is increased in bronchial biopsies from atopic and nonatopic asthmatics. J. Allergy Clin. Immun. 102: 859-66, 1998. (MT-13273)

124. D. L. Hamilos, D.Y.M. Leung, D.P. Huston, A. Kamil, R. Wood, Q. Hamid. GM-CSF, IL-5 and Rantes immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP). Clin Exp. Allergy 28: 1145-1152, 1998.

125. P. Stamatiou, Q. Hamid, R. Taha, W. Yu, T.B. Issekutz, J. Rokach, S.P. Khanapure, W.S. Powell. 5-Oxo-6,8,11,15-eicosatetraenoic induces pulmonary eosionophils in an integrin-dependent manner in Brown Norway rats. J. Clin. Invest. 102: 2165-2172, 1998.

126. A. Kamil, O. Ghaffar, F. Lavigne, R. Taha, P.M. Renzi, Q.A. Hamid. Comparison of inflammatory cell profile and Th2 cytokine expression in the ethmoid sinus, maxillary sinus, and turbinate of atopic subjects with chronic sinusitis. Otolarygol.Head,Neck Surg. 118: 804-809, 1998.

127. O. Ghaffar, F. Lavigne, A. Kamil, P.M. Renzi, Q.A. Hamid. IL-6 expression in chronic sinusitis. Co-localization of gene transcripts to eosinophils, macrophages, T lymphocytes, and mast cells. Otolaryngol. Head, Neck Surg. 118: 504-511, 1998.

128. A.T. Kotsimbos and Q. Hamid. Lymphocytes in asthma (Review). Canadian Respiratory Journal 5: 27-30, 1998.

129. G. Menz, S. Ying, S. R. Durham, C. J. Corrigan, D. S. Robinson, Q.A. Hamid, R. Pfister, M. Humbert, A. B. Kay. Molecular concepts of IgE-initiated inflammation in atopic and nonatopic asthma. [Review] [57 refs]. Allergy 53: 15-21, 1998.

130. E. Minshall, Q.A. Hamid. Cytokine expression in bronchial asthma. [Review]. Canadian Respiratory Journal 5: 30-32, 1998.

131. K.T. Nouri-Aria, K. T., K. Masuyama, M. R. Jacobson, S. Rak, O. Lowhagen, E. Schotman, Q.A. Hamid, and S. Durham. Granulocyte/macrophage-colony stimulating factor in allergen-induced rhinitis: cellular localization, relation to tissue eosinophilia and influence of topical corticosteroid. International Archives of Allergy & Immunology 117: 248-254, 1998.

132. H. Mishima, M. Hojo, A. Watanabe, Q.A. Hamid, J.G. Martin. CD4+ T cells can induce airway hyperresponsiveness to allergen challenge in the BN rat. Am. J. Respir. Crit. Care Med. 158: 1863-1870, 1998.

133. R.A. Taha, E.M. Minshall, R. Olivenstein, D. Ihaku, B. Wallaert, A. Tsicopoulos, A-B. Tonnel, R. Damia, D. Menzies, Q. Hamid. Increased expression of IL-12 receptor mRNA in active pulmonary tuberculosis and sarcoidosis. Am J. Respir. Crit. Care Med. 160: 1-6, 1999.

134. S. Laberge, S. Pinsonneault, P. Ernst, R. Olivenstein, O. Ghaffar, D.M. Center, Q. Hamid. Phenotype of IL-16-producing cells in bronchial mucosa: Evidence for the human eosinophil and mast cell as cellular sources of IL-16 in asthma. Int. Arch. Allergy Immunol. 119: 120-125, 1999.

135. A. Sauty, M. Dziejman, R.A. Taha, A.S. Iarossi, K. Neote, E. A. Garcia-Zepeda, Q. Hamid, A.D. Luster. The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells. J. Immunol. 162: 3549-3558, 1999.

136. D.L. Hamilos, S.E. Thawley, M.A. Kramper, A. Kamil, Q.A. Hamid. Effect of intranasal fluticasone on cellular infiltration, endothelial adhesion molecule expression, and proinflammatory cytokine mRNA in nasal polyp disease. J. Allergy Clin. Immunol. 103: 79-87, 1999.

137. R. Taha, E.M. Minshall, D. Miotto, A. Shimbara, A. Luster, J.C. Hogg, Q.A. Hamid. Eotaxin and MCP-4 mRNA expression in small airways of asthmatic and non-asthmatic individuals. J. Allergy Clin. Immunol. 103:476-483, 1999.

138. H. Kondo, D. Nachtigal, S. Frenkiel, E. Schotman, Q. Hamid. Effect of steroids on nasal inflammatory cells and cytokine profile. Laryngo. 109: 91-97, 1999.

139. Y. Nakamura, O. Ghaffar, R. Olivenstein, R.A. Taha, A. Soussi-Gounni, D-H. Zhang, A. Ray, Q.A. Hamid. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. J. Allergy Clin. Immunol. 103:215-222, 1999.

140. R. Olivenstein, R. Taha, E.M. Minshall, Q.A. Hamid. IL-4 and IL-5 mRNA expression in induced sputum of asthmatic subjects: Comparison with bronchial wash. J. Allergy Clin Immunol. 103: 238-245, 1999.

141. Y. Bastien, B.J. Toledano, N. Mehio, L. Cameron, B. Lamkhioued, P. Renzi, Q. Hamid, B.D. Mazer. Detection of functional platelet-activating factor receptors on human tonsillar B lymphocytes. J . Immunol. 162: 5498-5505, 1999.

142. D.S. Robinson, R. Damia, K. Zeibecoglou, S. Molet, J. North, T. Yamada, A.B. Kay, Q. Hamid. CD34+/IL-5R" mRNA+ cells in the bronchial mucosa in asthma: potential airway eosinophil progenitors. Am. J. Respir. Cell Mol. Biol. 20:9-13, 1999.

143. Q. Hamid, S.E. Wenzel, P.J. Hauk, A. Tsicopoulos, B. Wallaert, J.J. Lafitte, G.P. Chrousos, S. J. Szefler, DYM Leung. Increased glucocorticoid receptor $ in airway cells of glucocorticoid-insensitive asthma. Am. J. Respir. Crit. Care Med. 159: 1600-1604, 1999.

144. O. Ghaffar, Q. Hamid, P.M. Renzi, Z. Allakhverdi, S. Molet, J.C. Hogg, S.A. Shore, A.D. Luster, B. Lamkhioued. Constitutive and cytokine-stimulated expression of eotaxin by human airway smooth muscle cells. Am. J. Respir. Crit. Care Med. 159: 1933-1942, 1999.

145. E.M. Varga, M.R. Jacobson, S.J. Till, K. Masuyama, F. O’Brien, S. Rak, V. Lund, G.K. Scadding, Q.A. Hamid, S.R. Durham. Cellular infiltration and cytokine mRNA expression in perennial allergic rhinits. Allergy 54: 338-345, 1999.

146. S. Molet, Ramos-Barbon, J.G. Martin, Q.A. Hamid. Adoptively transferred late allergic response is inhibited by interleukin-4, but not interleukin-5, antisense oligonucleotide. J. Allergy Clin. Immunol. 104: 205-214, 1999.

147. J. Huang, R. Olivenstein, R.Taha, Q. Hamid, M. Ludwig. Enhanced proteoglycan deposition in the airway wall of atopic asthmatics. Am. J. Respir. Crit. Care Med. 160: 725-729, 1999.

148. P. Christodoulopoulos, E. Wright, S. Frenkiel, A. Luster, Q. Hamid. Monocyte chemotactic proteins in allergic-induced inflammation in the nasal mucosa. Effect of topical corticosteroids. J. Allergy Clin. Immunol. 103: 1036-1044, 1999.

149. S.R. Durham, S.M. Walker, E.M. Varga, M. Jacobson, F. O’Brien, W. Noble, S.J. Till, Q.A. Hamid,K. Nouri-Aria. Long-term clinical efficacy of of grass pollen immunotherapy. N. Engl. J. Med. 341: 468-475, 1999.

150. E.D. Wright, P. Christodoulopoulos, S. Frenkiel, Q. Hamid. Expression of IL-12 (p40) and IL-12 ($2) receptors in allergic rhinitis and chronic sinusitis. Clin. Exp. Allergy 29: 1320-1325, 1999.

151. E.D. Wright, P. Christodoulopoulos, S. Frenkiel;, Q. Hamid. IL-12 and allergic tissue expression. Editorial. Clin. Exp. Allergy 29: 1290-1300, 1999.

152. L.A. Cameron, R.A. Taha, A. Tsicopoulos, M. Kurimoto, R. Olivenstein, B. Wallaert, E.M. Minshall, Q.A. Hamid. Airway epithelium expresses IL-18. Eur. Respir. J. 14:553-559, 1999.

153. M. Suzuki, R. Taha, , Q. Hamid, J.G. Martin. CD8+ T cells modulate late allergic airway responses in Brown-Norway rats. J. Immunol. 163: 5574-5581, 1999.

154. D. Ihaku, L. Cameron, M. Suzuki, S. Molet, J. Martin, Q.Hamid. Montelukast, a leukotriene receptor antagonist, inhibits the late airway response to antigen, airway eosinophilia, and IL-5-expressing cells in Brown Norway rats. J. Allergy Clin. Immunol. 1147-54, 1999.

155. J.B. Travers, Q.A. Hamid, D.A. Norris, C. Kuhn, R.C.Gioro, P.M. Schlievert, E.R. Farmer, D.Y.M. Leung. Epidermal HLA-DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis. J. Clin. Invest. 104: 1181-1189, 1999.

156. Robinson, D.S., J. North, K. Zeibecoglou, S. Ying, Q. Meng, S. Rankin, Q. Hamid, J. Tavernier, A.B. Kay. Eosinophil development and bone marrow and tissue eosinophils in atopic asthma. Int. Arch Allergy Immunol. 118: 98-100, 1999.

157. E.M. Varga, M.R. Jacobson, K. Masuyama, S. Rak, S.J. Till, Y. Darby, Q.A. Hamid, V. Lund, G.K. Scadding, S.R. Durham. Inflammatory cell populations and cytokine mRNA expression in the nasal mucosa of aspirin sensitive rhinitis. Eur. Respir. J. 14: 610-615,1999.

158. Q.A. Hamid and E.M. Minshall. Molecular pathology of allergic disease. I: Lower airway disease. J. Allergy Clin. Immunol. 105: 20-36, 2000.

159. A. Shimbara, P. Christodoulopoulos, A.Soussi-Gounni, R. Olivenstein, Y. Nakamura, R.C. Levitt, N.C. Nicolaides, K.J. Holroyd, A. Tsicopoulos, J-J Lafitte, B. Wallaert, Q.A. Hamid. IL-9 and its receptor in allergic and non-allergic lung disease: Increased expression in asthma. J. Allergy Clin. Immunol. 105: 108-115, 2000.

190. A. Tsicopoulos, A. Janin, H. Akoum, C. Lamblin, H. Vorng, Q. Hamid, A-B. Tonnel, B. Wallaert. Cytokine profile in minor salivary glands from patients with bronchial asthma. J. Allergy Clin. Immunol. 106: 687-696, 2001.

191. A. Soussi-Gounni, L. Koussih, E. Nutku, L. Cameron, B. Lamkhioued, N.C. Nicolaides, R.C. Levitt, Q. Hamid. Functional expression of IL-9 receptor by human neutrophils from asthmatic donors. Role in IL-8 release. J. Immunol. 166: 2768-2774, 2001.

192. R.A. Taha, R. Olivenstein, Q.A.Hamid. Immunopathology of pulmonary tuberculosis: Role of cytokines. Can. J. Allergy & Clin. Immunol. 6: 16-24, 2001.

193. P. Christodoulopoulos, L. Cameron, Y. Nakamura, C. Lemiere, S. Muro, M. Dugas, L-P. Boulet, M. Laviolette, R. Olivenstein, Q. Hamid. Th2 cytokine-associated transcription facts in atopic and nonatopic asthma: Evidence for differential signal transducer and activator of transcription 6 expression. J. Allergy Clin. Immunol. 107: 586-591, 2001.

194. D. Miotto, P. Christodoulopoulos, R. Olivenstein, R. Taha, L. Cameron, A. Tsicopoulos, A-B. Tonnel, O. Fahy, J.J. Lafitte, A.D. Luster, B. Wallaert, C. E. Mapp, Q. Hamid. Expression of IFN-(- inducible protein: monocyte chemotactic proteins 1,3, and 4; and eotaxin in Th1- and Th2-mediated lung diseases. J. Allergy Clin. Immunol. 107: 664-670, 2001.

195. H. Iijima, A. Duguet, Seok-Yong Eum, Q. Hamid, D.H. Eidelman. Nitric oxide and protein nitration are eosinophil dependent in allergen challenge mice. Am. J. Respir. Crit. Care Med. 163: 1233-1240, 2001.

196. A. Soussi-Gounni, B. Lamkhioued, L. Koussih, C. Ra, P.M. Renzi, Q. Hamid. Human neutrophils express the high affinity receptor for IgE: Role in asthma. FASEB J. 15: 940-949, 2001.

197. C. Lamblin, F. Bolard, P. Gosset, A. Tsicopoulos, T. Perez, J. Darras, A. Janin, A. Bernard, Q. Hamid, B. Wallaert. Bronchial interleukin-5 and eotaxin expression in nasal polyposis. Am. J. Respir. Crit. Care Med. 163: 1226-1232, 2001.

198. M. Kraft, Q. Hamid, G.P. Chrousos, R.J. Martin, D.Y.M. Leung. Decreased steroid responsiveness at night in nocturnal asthma. Am. J. Respir. Crit. Care Med. 163: 1219-1225, 2001.

199. A. Soussi-Gounni, M. Kontolemos, Q. Hamid. Role of interleukin-9 in the pathophysiology of allergic diseases. J. Allergy Clin. Immunol. 107: 575-582, 2001.

200. S. Muro, Q. Hamid. (REVIEW). Advances in the pathophysiology of bronchial asthma. Allergology International 50: 119-131, 2001.

201. D.L. Hamilos, D.Y.M. Leung, S. Muro, A.M. Kahn, S.S. Hamilos, S.E. Thawley, Q.A. Hamid. GRB expression in nasal polyp inflammatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone. J. Allergy Clin. Immunol.108: 59-68, 2001.

202. M. Hoshino, Y. Nakamura, Q. Hamid. Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma. J. Allergy Clin. Immunol. 107:1034-1038, 2001.

203. R.A. Taha, S. Laberge, Q. Hamid, R. Olivenstein. Increased expression of the chemoattractant cytokines, eotaxin, MCP-4 and IL-16 in induced sputum in asthmatics. Chest 120: 595-601, 2001.

204. E. Nutku, Q. Zhuang, A. Soussi-Gounni, F. Aris, B.D. Mazer, Q. Hamid. Functional expression of interleukin-12R by human eosinophils: IL-12 promotes eosinophil apopotosis. J. Immunol. 167: 1039-1046, 2001.

205. A. Duguet, H. Iijima, S-Y. Eum, Q. Hamid, D.H. Eidelman. Eosinophil peroxidase mediates protein nitration in allergic airway inflammation in mice. Am. J. Respir. Crit. Care Med. 164: 1119-1126, 2001.

206. S. Molet, Q. Hamid, F. Davoine, E. Nutku, R. Taha, N. Page, R. Olivenstein, J. Elias, J. Chakir. IL-17 is increased in asthmatic airways and induces human fibroblasts to produce profibrotic cytokines. J. Allergy Clin. Immunol. 108: 430-438, 2001.

207. J-P. Lavoie, K. Maghni, M. Desnoyers, R. Taha, J.G. Martin and Q.A. Hamid. Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile. Am. J. Respir. Crit. Care Med. 164: 1410-1413, 2001.

208. S. Muro, R. Taha, A. Tsicopoulos, R. Olivenstein, A-B. Tonnel, P. Christodoulopoulos, B. Wallaert, Q. Hamid. Expression of IL-15 in inflammatory pulmonary diseases. J. Allergy Clin. Immunol. 108:970-975, 2001.

209. Z. Zhu, C.G. Lee, T. Zheng, G. Chupp, J. Wang, R.J. Homer, P.W. Noble, Q. Hamid, J.A.Elias. Airway inflammation and remodeling in asthma: Lessons from IL-11 and IL-13 transgenic mice. Am. J. Respir. Crit. Care Med. (Review) 164: S67-70, 2001.

210. M.K. Tulic, P. Christodoulopoulos, Q. Hamid. Small airway inflammation in asthma (Review). Respir. Res. 2: 333-339, 2001.

211. C. Lemiere, R. Taha, R. Olivenstein, Q. Hamid. Comparison of cellular composition of induced sputum analyzed with Wright staining and immunocytochemistry. J. Allergy Clin. Immunol. 108: 521-523, 2001.

212. P.Y.Ong, Q. Hamid, J.B. Travers, I. Strickland, M. Al Kerithy, M. Boguniewicz, D.Y.M. Leung. Decreased IL-15 may contribute to elevate IgE and acute inflammation in atopic dermatitis. J. Immunol. 168: 505-510, 2002.

213. M. Toda, M.K. Tulic, R.C. Levitt, Q. Hamid. A calcium-activated chloride channel (HCLCA1) is strongly related to interleukin-9 expression and mucus production in bronchial epithelium of patients with asthma. J. Allergy Clin. Immunol. 109: 246-250, 2002.

214. V. Gemou Engesaeth, M.K. Fagerhol, M. Toda, Q. Hamid, S. Halvorsen, J.B. Groegaard, C.J. Corrigan. Expression of activation markers and cytokine mRNA by peripheral blood CD4 and CD8 T cells in atopic and non-atopic childhood asthma: Effect of inhaled glucocorticoid therapy. Pediatrics 109: 1-9, 2002.

215. M. Suzuki, K. Maghni, S. Molet, A. Shimbara, Q. Hamid, J.G. Martin. IFN-gamma secretion by CD8+ T cells inhibits allergen-induced airway eosinophilia but not late airway responses. J. Allergy Clin. Immunol. 109: 803-809, 2002.

216. F. Lavigne, L. Cameron, P. Renzi, J-F. Planet, P. Christodoulopoulos, B. Lamkhioued, Q. Hamid. Intrasinus administration of topical budesonide to allergic patients with chronic rhinosinusitis following surgery. Laryngoscope, 112: 858-86, 2002.

217. Senechal S, Fahy O, Gentina T, Vorng H, Capron M, Walls AF, McEuen AR, Buckley MG, Hamid Q, Wallaert B, Tonnel AB, Tsicopoulos A. CCR3-blocking antibody inhibits allergen-induced eosinophil recruitment in human skin xenografts from allergic patients. Lab Invest. 82:929-39, 2002.

218. S.E. Sobol, R. Taha, M.D.Schloss, B.D.Mazer, J.J. Manoukian, T.L. Tewfik, Q. Hamid. Th2 cytokine expression in atopic children with otitis media with effusion. J. Allergy Clin. Immunol. 110: 125-130, 2002.

219. L.N. Tremblay, D. Miotto, Q. Hamid, A. Govindarajan, A.S. Slutsky. Injurious ventilatory induce widespread pulmonary epithelial expression of TNF-" and IL-6 mRNA. Am. J. Crit. Care Med. 30:1693-1700, 2002.

220. J. Chakir, Q. Hamid, M. Bosse, L-P. Boulet, M. Laviolette. Bronchial inflammation in corticosteroid-sensitive and -resistant asthma at baseline and on oral corticosteroid treatment. Clin. Exp. Allergy 32: 578-582, 2002.

221. L.J. Wood, R. Sehmi, S. Dorman, Q. Hamid, M.K. Tulic, R.M. Watson, R. Foley, P. Wasi, J.A. Denburg, G. Gauvreau, P.M. O’Byrne. Allergen-induced increases in bone marrow T- lymphocytes and interleukin-5 expression in asthmatic subjects. Am. J. Crit. Care Med. 166: 883-889, 2002.

222. S.E. Sobol, P. Christodoulopoulos, J.J. Manoukian, H.P. Hauber, S. Frenkiel, M. Desrosiers, M. Fukakusa, M.D. Schloss, Q. Hamid. Cytokine profile of chronic sinusitis in patients with cystic fibrosis. Arch. Otolaryngol. Head Neck Surg. 128: 1295-1298, 2002.

223. M.K. Tulic, J.J. Manoukian, D.H. Eidelman, Q. Hamid. T-cell proliferation induced by local application of LPS in the nasal mucosa of nonatopic children. J. Allergy Clin. Immunol. 110: 771-776, 2002.

224. A. Efthimiadis, A. Spanevello, Q. Hamid, M.M. Kelly, M. Linden, R. Louis, M.M. Pizzichini, E. Pizzichini, C. Ronchi, F. Van Overvel, R. Djukanovic. Methods of sputum processing for cell counts, immunocytochemistry and in situ hybridization. Eur. Respir. J. Suppl. 37: 19s-23s, 2002.

225. J.G. Martin, M. Suzuki, K. Maghni, R. Pantano, D. Ramos-Barbon, D. Ihaku, F. Nantel, D. Denis, Q. Hamid, W.S. Powell. The immunomodulatory actions of prostraglandin E2 on allergic airway responses in the rat. J. Immunol. 169: 3963-3969, 2002.

226. S. Fakhri, S. Frenkiel, Q. Hamid. Current views on the molecular biology of chronic sinusitis. J. Otolaryngol. 31, Suppl. 1: S2-9, 2002.

227. M. Desrosiers, S. Frenkiel, Q. Hamid, D. Low, P. Small, S. Carr, M. Hawke, D. Kirkpatrick, F. Lavigne, L. Mandell, H.E. Stevens, K. Weiss, I.J. Witterick, E.D. Wright, R. Davidson. Acute bacterial sinusitis in adults: Management in the primary care setting. J. Otolaryngol. 31 (Suppl. 2): 2S2-14, 2002.

228. L. McNaughton, L. Puttagunta, M.A. Martinez-Cuesta, N. Kneteman, I. Mayers, R. Moqbel, Q. Hamid. Distribution of nitric oxide synthase in normal and cirrhotic human liver. Proc. Natl Acad. Sci. 99: 17161-17166, 2002.

229. C. McCusker, M. Chicoine, Q. Hamid, B. Mazer. Site-specification in a murine model of allergic rhinitis: Role of the upper airway in lower airways diseases. J. Allergy Clin. Immunol. 110: 891-898, 2002.

230. B. Lamkhioued, Q. Hamid, A. Soussi-Gounni, G. Delespesse, P.M. Renzi. The CCR3 is involved in eosinophil differentiation and is upregulated by Th2 cytokines in CD34+ progenitor cells. J. Immunol. 170: 537-547, 2003.

231. Q. Hamid. Gross pathology and histopathology of asthma. J. Allergy Clin. Immunol. 111: 431-432, 2003.

232. Q. Hamid, M.K. Tulic, M.C. Liu, R. Moqbel. Inflammatory cells in asthma: Mechanisms and implications for therapy. J. Allergy Clin. Immunol. 111 (Suppl): S5-S12, S12-17, 2003.

233. S.Y. Eum, K. Maghni, Q. Hamid, D.H. Eidelman, H. Campbell, S. Isogai, J.G. Martin. Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: Role of eosinophils, IL-5, eotaxin, and IL-13. J. Allergy Clin. Immunol. 111: 1049-1061, 2003.

234. M.D. Schloss, S.E.Sobol, Q. Hamid. The role of allergies in the pathogenesis of otitis media and effusion. J. New Develop. Clin. Med. 21: 15-26, 2003.

235. S.E. Sobol, M. Fukakusa, P. Christodoulopoulos, J.J. Manoukian, M.D. Schloss, S. Frenkiel, Q. Hamid. Inflammation and remodeling of the sinus mucosa in children and adults with chronic sinusitis. Laryngoscope 113:410-414, 2003.

236. M. Toda, D.Y.M. Leung, S. Molet, M. Boguniewicz, R. Taha, P. Christodoulopoulos, T. Fukuda, J.A. Elias, Q. Hamid.. Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions. J. Allergy Clin. Immunol. 111: 875-881, 2003.

237. R. Taha, Q. Hamid, L. Cameron, R. Olivenstein. T helper type 2 cytokine receptors and associated transcription factors GATA3, c-MAF, and signal transducer and activator of transcription factor-6 in induced sputum of atopic asthmatic patients. Chest 123: 2074-2082, 2003.

238. M.K. Tulic, Q. Hamid. Contribution of the distal lung to the pathologic and physiologic changes in asthma: Potential therapeutic target Roger S. Mitchell lecture. Chest 123: (3 Suppl) 348-355S, 2003(Review).

239. B.S. Bochner, Q. Hamid. Advances in mechanisms of allergy. J. Allergy Clin. Immunol. 111: (3 Suppl): S819-S823, 2003 (Review).

240. J. Chakir, J. Shannon, S. Molet, M. Fukakusa, J. Elias, M. Laviolette, L.P. Boulet, Q. Hamid. Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-$, IL-11, IL-17 and Type I and II collagen expression. J. Allergy Clin. Immunol. 111: 1293-1298, 2003.

241. H.P. Hauber, J.J. Manoukian, L.H.. Nguyen, S.E. Sobol, R.C. Levitt, K.J. Holroyd, N.G. McElvaney, S. Griffin, Q. Hamid. Increased expression of IL-9, IL-9 receptor and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cysitic fibrosis. Laryngoscope 113: 1037-1042, 2003.

242. P.O. Fiset, A. Soussi Gounni, P. Christodoulopoulos, M. Tulic, S.E. Sobol, S. Frenkiel, F. Lavigne, B. Lamkhioued, Q. Hamid. Modulation of allergic response in nasal mucosa by antisense oligodeoxynucleotides for IL-4. J. Allergy Clin. Immunol. 111: 580-586, 2003.

243. J-P. Lavoie, K. Maghni, R. Taha, X.X. Yang, G.M. Lang, A.H. Sehon, Q.A. Hamid, J.G. Martin. Conjugates of ovalbumin and monomethoxypolyetheylene glycol abolish late allergic responses and decrease IL-4 and IL-5 mRNA expression in the rat. Pulm. Pharmacol. Ther. 16: 361-369, 2003.

244. H.P. Hauber, M. Gotfried, K. Newman, R. Danda, R.J. Servi, P. Christodoulopoulos, Q. Hamid. Effect of HFA-flunisolide on peripheral lung inflammation in asthma. J. Allergy Clin. Immunol. 112: 58-63, 2003.

245. M.K. Tulic, P.O. Fiset, P. Christodoulopoulos, P. Vaillancourt, M. Desrosiers, F. Lavigne, J. Eiden, Q. Hamid. AMB A 1-immunostimulatory oligodeoxyribonucleotide conjugate immunotherapy decreases the nasal mucosal inflammatory response. J. Allergy Clin. Immunol. 113: 235-241, 2003.

246. N. Zimmermann, N.E. King, J. Laporte, M. Yang, A. Mishra, S.M. Pope, E.E. Muntel, D.P. Witte, A.A. Pegg, P.S. Foster, Q. Hamid, M.E. Rothenberg. Dissection of experimental asthma with DNA microarray analysis: Identifies arginase in asthma pathogenesis. J. Clin. Invest. 111:1863-1874, 2003.

247. I. Nomura, E. Goleva, M.D. Howell, Q. Hamid, P.Y. Ong, C.F. Hall, M.A. Darst, B. Gao, M. Boguniewicz, J.B. Travers, D.Y.M. Leung. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J. Immunol. 171: 3262-3269, 2003.

248. L. Cameron, A. Soussi Gounni, S. Frenkiel, F. Lavigne, D. Vercelli, Q. Hamid. S,S: and S,S( switch circles in human nasal mucosa following ex vivo allergen challenge: Evidence for direct as well as sequential class switch recombination. J. Immunol 171: 3816-3822, 2003.

249. S. Fakhri, P. Christodoulopoulos, M.Tulic, M. Fukakusa, S. Frenkiel, D.Y. Leung, Q.A. Hamid. Role of microbial toxins in the induction of glucocorticoid receptor and beta: Expression in an explant model of rhinosinusitis. J. Otolaryngol. 32: 388, 2003.

250. S. Muro, Q. Hamid, R. Olivenstein, R. Taha, J. Rokach, W.S. Powell. 5-oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin. J. Allergy Clin. Immunol. 112: 768-774, 2003.

251. L.H. Nguyen, S.Fakhri, S. Frenkiel, Q.A. Hamid. Molecular immunology and immunotherapy for chronic sinusitis. Curr. Allergy Asthma Rep. 3: 505-512, 2003 (Review).

252. S.M. Molet, Q.A. Hamid, D.L. Hamilos. IL-11 and IL-17 expression in nasal polyps: Relationship to collagen deposition and suppresion by intranasal fluticasone propionate. Laryngoscope 113: 1803-1812, 2003.

253. C. Bergeron, N. Page, P. Joubert, B. Barbeau, Q. Hamid, J. Chakir. Regulation of procollagen I (alpha 1) by IL-4 in human brnchial fibroblasts: A possible role in airway remodeling in asthma. Clin. Ex. Allergy 33: 1389-1397, 2003.

254. Q. Hamid. Effects of steroids on inflammation and cytokine gene expression in airway inflammation. J. Allergy Clin. Immunol. 112: 636-638, 2003.

255. S. Isogai, A. Rubin, K. Maghni, D.Ramos-Barbon, R. Taha, Y. Yoshizawa, Q. Hamid J.G. Martin. The effects of CD8+ gamma deltaT cells on late allergic airway responses and airway inflammation. J. Allergy Clin. Immunol. 112: 547-555, 2003.

256. Q. Hamid. Airway remodeling in asthma. J. Allergy Clin. Immunol. 111: 1420-1421, 2003.

257. J.G. Martin. H.R. Campbell, H. Iijima, D. Gautrin, J.L. Malo, D.H. Eidelman, Q. Hamid, K. Maghni. Chlorine-induced injury to the airways in mice. Am. J. Respir. Crit. Care Med. 168: 568-574, 2003.

258. Q. Hamid. Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situe hybridization. J. Allergy Clin. Immunol. 111: 902-903, 2003.

259. A. Menzies-Gow, P. Flood-Page, R. Sehmi, J. Burman, Q. Hamid, D.S. Robinson, A.B. Kay, J. Denburg. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J. Allergy Clin. Immunol. 111: 714-719, 2003.

260. P. Panzner, J.J. Lafitte, A. Tsicopoulos, Q. Hamid, M.K. Tulic. Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patientns with chronic bronchitis with obstruction. Chest 124: 1909-1915, 2003.

261. Q. Hamid. Eosinophils in allergic inflammation. J. Allergy Clin. Immunol. 113: 182-184, 2004.

262. M.E. Cordeau, P. Joubert, O. Al Dewachi, Q. Hamid, J.P. Lavoie. IL-4, IL-5 and IFN-gamma mRNA expression in pulmonary lymphocytes in equine heaves. Vet. Immunol Immunopathol. 97: 87-96, 2004.

263. H.P. Hauber, A.Tsicopoulos, B. Wallaert, S. Griffin, N.G. McElvaney, P. Daigneault, Z. Meuller, R. Olivestein, K.J. Holroyd, R.C. Levitt, Q. Hamid. Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. Eur. Respir. J. 23: 846-850, 2004.

264. Q. Hamid. Molecular pathology of immunotherapy. J. Allergy Clin. Immunol. 113: 1234-1237, 2004.

265. M.S. Ludwig, N. Ftouhi-Paquin, W. Huang, N. Page, J. Chakir, Q. Hamid. Mechanical strain enhances proteoglycan message in fibroblasts from asthmatic subjects. Clin. Exp. Allergy 34: 926-930, 2004.

266. Z. Zhu, T. Zheng, R.J. Homer, Y.K. Kim, N.Y. Chen, L. Cohn, Q. Hamid, J.A. Elias. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 304: 1678-1682, 2004.

267. M.K. Tulic, P.O. Fiset, J.J. Manoukian, S. Frenkiel, F. Lavigne, D.H. Eidelman, Q. Hamid. Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults. Lancet 363: 1689-1697, 2004.

268. J.H. Boyd, B.J. Petrof, Q. Hamid, R. Fraser, R.J. Kimoff. Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. Am J. Respir. Crit. Care Med. 170: 541-546, 2004.

269. H.P. Hauber, C. Bergeron, Tulic, Q. Hamid. IL-9 in allergic inflammation. Int. Arch. Allergy Immunol. 134: 79-87, 2004.

270. Q. Hamid, B. Mazer. Immunopathology of food allergy. J. Allergy Clin. Immunol. 113: 1006-1008, 2004.

271. S. Fakhri, M.Tulic, P. Christodoulopoulos, M. Fukakusa, S. Frenkiel, D.Y. Leung, Q. Hamid. Microbial superantigens induce glucocorticoid receptor beta and steroid resistance in a nasal explant model. Laryngoscope 114: 887-892, 2004.

272. R. Taha, Q. Hamid, R. Olivenstein. Fractional analysis of Th2-type cytokines in sequential samples of induced sputum. Can. Respir. J. 11: 146-150, 2004.

273. S. Al-Muhsen, G. Shablovsky, R. Olivenstein, B. Mazer, Q. Hamid. The expression of stem cell factor and c-kit receptor in human asthmatic airways. Clin. Exp. Med. 34: 911-916, 2004.

274. S. Isogai, S. Miyata, R. Taha, Y. Yoshizawa, J.G. Martin, Q. Hamid. CD4+ T cells migrate from airway to bone marrow after antigen inhalation in rats. J. Allergy Clin. Immunol. 113: 455-461, 2004.

275. A. Tsicopoulos, A. Shimbara, S. Senechal, O. AlDewachi, C. Lamblin, P. Lassalle, A.F. Walls, P. de Nadai, R. Levitt, J. Darras, A.B. Tonnel, Q. Hamid, B. Wallaert. Involvement of IL-9 in the bronchial phenotype of patients with nasal polyposis. J. Allergy Clin. Immunol. 113: 462-469, 2004.

276. D.Y. Leung, M. Boguniewicz, M.D. Howell, I. Nomura, Q.A. Hamid. New insights into atopic dermatitis. J. Clin. Invest. 113: 651-670, 2004.

277. M.K. Tulic, P.O. Fiset, P. Christodoulopoulos, P. Vaillancourt, M. Desrosiers, F. Lavigne, J. Eiden, Q. Hamid. Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. J. Allergy Clin. Immunol. 113: 235-241, 2004.

278. Q. Hamid. Eosinophils in allergic inflammation. J. Allergy Clin. Immunol. 113: 182-184, 2004.

279. M.E. Cordeau, P. Joubert, O. Dewachi, Q. Hamid, J.P. Lavoie. IL-4, IL-5 and IFN-gamma mRNA expression in pulmonary lymphocytes in equine heaves. Vet. Immunol. Immunopathol. 97: 87-96, 2004.

280. O. Hajoui, R. Janani, M. Tulic, P. Joubert, T. Ronis, Q. Hamid, H. Zheng, B.D. Mazer. Synthesis of IL-13 by human B lymphocytes: Regulation and role in IgE production. J. Allergy Clin. Immunol. 114: 657-663, 2004.

281. S.J. Hirst, J.G. Martin, J.V. Bonacci, V. Chan, E.D. Fixman, Q.A. Hamid, B. Herszberg, J.P. Lavoie, C.G. McVicker, L.M. Moir, T.T. Nguyen, Q. Peng, D. Ramos-Barbon, A.G. Stewart. Proliferative aspects of airway smooth muscle. J. Allergy Clin. Immunol. 114: S2-17 (Review), 2004.

282. A.S. Gounni, Q. Hamid, S.M. Rahman, J. Hoeck, J. Yang, L. Shan. IL-9-mediated induction of eotaxin 1/CCL11 in human airway smooth muscle cells. J. Immunol. 173: 2771-2229, 2004.

283. F. Lavigne, M.K. Tulic, J. Gagnon, Q. Hamid. Selective irrigation of the sinuses in the management of chronic rhinosinusitis refractory to medical Selective irrigation of the sinuses in the management of chronic rhinosinusitis refractory to medical therapy: a promising start. J Otolaryngol. 33:10-16, 2004.

284. S. Isogai, R. Taha, Y. Yoshizawa, Q. Hamid, J.G. Martin. CD+aB T cells can mediate late airway responses and airway eosinophilia in rats. J. Allergy Clin. Immunol. 114: 1345-1352, 2004.

285. L.H.P. Nguyen, J.J. Manoukian, S.E. Sobol, T.L. Tewfik, B.D. Mazer, M.D. Schloss, R. Taha, Q.A. Hamid. Similar allergic inflammation in the middle ear and the upper airway: Evidence linking otitis media with effusion to the united airways concept. J. Allergy Clin. Immunol. 114: 1110-1115, 2004.

286. J.F. Bernardes, J. Shan, M. Tewfic, Q. Hamid, S. Frenkiel, D.H. Eidelman. Protein nitration in chronic sinusitis and nasal polyposis: role of eosinophils. Otolaryngol Head Neck Surg. 131: 696-703, 2004.

287. Q. Hamid, M. Cosio, S. Lim. Inflammation and remodeling in chornic obstructive pulmonary disease. J. Allergy Clin. Immunol. 114: 1479-1281, 2004.

288. H.P. Hauber, P.Daigneault, S. Frenkiel, F. Lavigne, H.L. Hung, R.C. Levitt, Q. Hamid. Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa. J. Allergy Clin. Immunol. 115: 266-271, 2005.

289. M. Fukakusa, C. Bergeron, M.K. Tulic, P.O. Fiset, O. Al Dewachi, M. Laviolette, Q. Hamid, J.Chakir. Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil. IL-8 and IFN-gamma-inducible protein 10 expression in asthmatic airway mucosa. J. Allergy Clin. Immunol. 115: 280-286, 2005.

290. V. Govindaraju, H. Teoh, Q. Hamid, P. Cernacek, M.E. Ward. Interaction between endothelial heme oxygenase-2 and endothelial-1 in altered aortic reactivity after hypoxia in rats. Am J. Physiol. Heart Circ. Physiol. H962-70, 2005.

291. W. Almishri, C. Cossette, J. Rokach, J.G. Martin, Q. Hamid, W. Powell. Effects of prostaglandin D2, 15-deoxy-d12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. J. Pharmacol. Exp. Ther. 313:64-69, 2005.

292. D. Ramos-Barbon, J.F. Presley, Q. Hamid, E.D. Fixman, J.G. Martin. Antigen-specific CD4+T cells drive airway smooth muscle remodeling through regulation of myocyte apoptosis and proliferation in experimental asthma. J. Clin. Invest. 115: 1580-1589, 2005.

293. P.O. Fiset, L. Cameron, Q. Hamid. Local isotype switching to IgE in airway smooth mucosa. J. Allergy Clin. Immunol. 116: 233-236, 2005.

294. H.P. Hauber, C. Bergeron, A. Tsicopoulos, B. Wallaert, R. Olivenstein, K.J. Holroyd, R.C. Levitt, Q. Hamid. Increased expression of the calcium-activated chloride channel in hCLCA1 in airways of patients with obstructive chronic bronchitis. Can. Respir. J. 12: 143-146, 2005.

295. C. Bergeron, L.P. Boulet, Q. Hamid. Obesity, allergy and immunology. J. Allergy Clin. Immunol. 115: 1102-1104 (Review), 2005.

296. H.P. Hauber, M.K. Tulic, A. Tsicopoulos, B. Wallaert, R. Olivenstein, P. Daigneault, Q. Hamid. Toll-like receptrors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis. Can Respir. J. 12: 13-18, 2005.

297. S. Isogai, S. Jedrzkiewicz, R. Taha, Q. Hamid, J.G. Martin. Resident CC8+T cell-dependent late allergic airway responses. J. Allergy Clin. Immunol. 115:521-526, 2005.

298. A. Soussi Gounni, V. Wellemans, J. Yang, F. Bellesort, K. Kassiri, S. Gangloff, M. Guenounou, A.J. Halayko, Q. Hamid, B. Lamkhioued. Human airway smooth muscle cells express the high affinity receptor for IgE (Fc,RI): A critical role of Fc,RI in human airway smooth muscle cell function. J. Immunol. 175: 2613-21, 2005.

299. P.O. Fiset, M.K. Tulic, Q. Hamid. Toll-like receptors and atopy. J. Allergy Clin. Immunol. 116: 467-70, 2005.

300. P. Joubert, S. Lajoie-Kadoch, I. Labonte, A.S. Gounni, K. Maghni, V. Wellemans, J. Chakir, M. Laviolette, Q. Hamid, B. Lamkhioued. CCR3 expression and function in asthmatic airway smooth muscle cells. J. Immunol. 175: 2702-8, 2005.

301. P.O. Fiset, Z. Muller, Q. Hamid. The impact of today’s technology on allergy research. Clin. Exp. Allergy 35: 846-8, 2005.

302. H. Iijima, M.K. Tulic, A. Duguet, J. Shan, P. Carbonara, Q. Hamid, D.H. Eidelman. NOS 1 is required for allergen-induces expression of NOS 2 in mice. Int. Arch Allergy Immunol. 138: 40-50, 2005.

303. C. Bergeron, H.P. Hauber, M. Gotfried, K. Newman, R. Dhanda, R. Servi, M.S. Ludwig, Q. Hamid. Evidence of remodeling in peripheral airways of mild to moderate asthmatic patients. J. Allergy Clin. Immunol. 116: 983-989, 2005.

304. C. Pepe, S. Foley, J. Shannon, S. Brunet, R. Olivenstein, P. Fiset, M.S. Ludwig, J.G. Martin, Q. Hamid. Differences in airway remodeling between severe and moderate asthma. J. Allergy Clin. Immunol. 116: 544-9, 2005.

305. P. Joubert, Q. Hamid. Role of airway smooth muscle in airway remodeling. J. Allergy Clin. Immunol. 116: 713-6, 2005.

306. O. Dewachi, P. Joubert, Q. Hamid, J.P. Lavoie. Expression of IL-5 and IL-9 receptors on neutrophils of horses with heaves. Vet. Immunol Immunopathol. 109: 31-36,2005.

307. J.A. Elias, R.J. Homer, Q. Hamid, C.G. Lee. Chitinases and chitinase-like proteins in Th2 inflammation and asthma. J. Allergy Clin. Immunol. 116: 497-500, 2005.

308. L. Pini, C. Torregiani, J.G. Martin, Q. Hamid, M.S. Ludwig. Airway remodeling in allergen challenged Brown Norway Rats: Distribution of proteoglycans. Am. J. Physiol. Lung Cell Mol. Physiol. 290(6): L1052-1058, 2006.

309. C. Bergeron, J. Kimoff, Q. Hamid. Obstructive sleep apnea syndrome and inflammation. J. Allergy Clin. Immunol. 116: 1393-1396, 2005.

310. B.D. Mazer, S. Al-Tamemi, J.W. Yu, Q. Hamid. Immune supplementation and immune modulation with intravenous immunoglobulin. J. Allergy Clin. Immunol. 116: 941-944, 2005.

311. Q. Hamid. Contribution of the distal lung to the pathologic changes in asthma-Potential therapeutic target. Japanese Allergology Society (proceedings) 2005.

312. P.O. Fiset, M. Tulic, P. Skrablin, S. Grover, S. Létuvé, B. Mazer, Q. Hamid. Signal transducer and activator of transcriptio 6 downregulates toll-like receptor-4 expression of a monocytic cell line. Clin. Exp. Med. 36: 158-165, 2006.

313. Q. Hamid. How can we improve our assessment of inflammation in clinical studies of COPD that use bronchial biopsies? Eur. Respir. J. 27: 248-249, 2006.

314. S. Lajoie-Kadoch, P. Joubert, S. Letuve, A.J. Halayko, J.G. Martin, A. Soussi-Gounni, Q. Hamid. TNF-a and IFN-g inversely modulate expression of the IL-17E receptor in airway smooth muscle cells. Am. J. Physiol. Lung Cell Mol Physiol. 290: L1238-46, 2006.

315. H.P. Hauber, C. Bergeron, M. Toda, M. Kontolemos, K.J. Holroyd, R.C. Levitt, Q. Hamid. Upregulation of IL-9 and the IL-9 associated calcium-activated chloride channel hCLCA1 in nasal mucosa following in vivo allerge challenge. Pulm. Pharmacol. Ther. (In Press)

316. H.P. Hauber, R. Taha, V. Migounov, Q. Hamid, R. Olivenstein. Effects of hydrofluoroalkane and dry powder-formulated corticosteroids on sputum inflammatory markers in asthmatic patients. Can. Respir. J. 13: 73-78, 2006.

317. M.K. Tulic. Q. Hamid. New insights into the pathophysiology of the small airways in asthma. Clin. Chest Med. 27: 41-52, 2006.

318. S. Foley, Q. Hamid. Severe asthma. J. Allergy Clin. Immunol. 117: 714-717, 2006.

319. C. Bergeron, M. Fukakusa, R. Olivenstein, C. Lemiere, J. Shannon, P. Ernst, J.G. Martin, Q. Hamid. Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthma. J. Allergy Clin. Immunol. 117: 703-705, 2006.

320. S. Letuve, S. Lajoie-Kadoch, S. Audusseau, M.E. Rothenberg, P.O. Fiset, M.S. Ludwig, Q. Hamid. IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. J. Allergy Clin. Immunol. 590-596, 2006.

321. Q. Hamid. How can we improve our assessment of inflammation in clinical studies of COPD that use bronchial biopsies? Eur. Respir. J. 27: 248-249, 2006.

322. P.O. Fiset, M.K. Tulic, P.S. Skrablin, S.M. Grover, S. Letuve, M.D. Mazer, Q. Hamid. Signal transducer and activator of transcription 6 down-regulates toll-like receptor-4 expression of a monocytic cell line. Clin. Exp. Allergy 36: 158-165, 2006.

323. S. Lajoie-Kadoch, P. Joubert, S. Letuve, A.J. Halayko, J.G. Martin, A. Soussi-Gounni, Q. Hamid. TNF-a and IFN-g inversely modulate expression of the IL-17E receptor in airway smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. Jan. 2006

324. M. Kraft, Q. Hamid. Mycoplasma in severe asthma. J. Allergy Clin. Immunol. 117:1197-98, 2006.

325. S. Plante, A. Semlali, P. Joubert, E. Bissonnette, M. Laviolette, Q. Hamid, J. Chakir. Mast cells regulate procollage I (alpha (1)) production by bronchial fibroblasts derived from subjects with asthma through IL-4/IL-4 delta 2 ratio. J. Allergy Clin. Immunol. 117: 1321-27, 2006.

326. F. LeBellego, S. Plante, J. Chakir, Q. Hamid, M.S. Ludwig. Differences in MAP kinase phosphorylation in response to mechanical strain in asthmatic fibroblasts. Respir. Res. 7: 68, 2006.

327. A. Soussi Gounni, V. Wellemans, M. Agouli, M. Guenounou, Q. Hamid, L.A. Beck, B. Lamkhioued. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin. Immunol. 120: 220-231, 2006.

328. N.N. Jarjour, S.J. Wilson, S.M. Koenig, M. Laviolette, W.C. Moore, W.B. Davis, D.E. Doherty, Q. Hamid, E. Israel, M.S. Kavuru, J.W. Ramsdell, D.P. Tashkin, D.S. Reilly, S.W. Yancey, L.D. Edwards, J.L. Stauffer, P.M. Dorinsky, R. Djukanovic. Control of airway inflammation maintained at a lower steroid dose with 100/50 microg of fluticasone propionate/salmeterol. J. Allergy Clin. Immunol. 118: 44-52, 2006.

329. P.O. Fiset, D.Y.Leung, Q. Hamid. Immunopathology of atopic dermatitis. J. Allergy Clin. Immunol. 118: 287-290, 2006.

330. C.A. Akdis, M. Akdis, T. Bieber, C. Bindslev-Jensen, M. Boguniewicz, P. Eigenmann, Q. Hamid, A. Kapp, D.Y. Leung, J. Lipozencic, T.A. Luger, A. Muraro, N. Novak, T.A. Platts-Mills, L. Rosenwasser, A. Schevnius, F.E. Simons, J. Spergel, K. Turjanmaa, U. Wahn, S. Weidinger, T. Werfel, T. Zuberbier. Diagnosis and treatment of atopic dermatitis in children and adults. Europeon Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. Allergy 61: 969-987, 2006.

331. P.O. Fiset, Q. Hamid. Chemokine expression in allergic diseases. J. Allergy Clin. Immunol. 118: 536-538, 2006.

332. H.P. Hauber, S.C. Foley, Q. Hamid. Mucin overproduction in chronic inflammatory lung disease. Can Respir. J. 13: 327-335, 2006.

333. C. Lemiere, P. Ernst, R. Olivenstein, Y. Yamauchi, K. Govindaraju, M.S. Ludwig, J.G. Martin, Q. Hamid. Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes. J. Allergy Clin. Immunol. 118: 1033-1039, 2006.

334. L. Pini, Q. Hamid, J. Shannon, L. Lemelin, R. Olivenstein, P. Ernst, C. Lemiere, J.G. Martin, M.S. Ludwig. Differences in proteoglycan deposition in the airway of moderate and severe asthmatics. Eur. Respir. J. 29: 71-77, 2007.

335. B.E. Kim, D.Y. Leung, J.E. Streib, M. Boguniewicz, Q. Hamid, M.D. Howell. Macrophage inflammatory protein 3 alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccine virus. J. Allergy Clin. Immunol. 119: 457-463, 2007.

336. D. Prefontaine, P.O. Fiset, Q. Hamid. Transcription factors in allergic disease. J. Allergy Clin. Immunol. 119: 761-764, 2007.

337. I. Ito, J.D. Laporte, P.O. Fiset, K. Asai, Y. Yamauchi, J.G. Martin, Q. Hamid. Downregulation of a disintegrin and metalloproteinase 33 by IFN-g in human airway smooth muscle cells. J. Allergy Clin. Immunol. 119: 89-97, 2007.

338. C. Bergeron, L.P. Boulet, N. Page, M. Laviolette, N. Zimmermann, M.E. Rothenberg, Q. Hamid. Influence of cigarette smoke on the arginine pathway in asthmatic airways : increased expression of arginase-I. J. Allergy Clin. Immunol. 119: 391-397, 2007.

339. C. Bergeron, M.K. Tulic, Q. Hamid. Tools used to measure airway remodeling in research. Eur. Respir. J. 29: 596-604, 2007.

340. S.C. Foley, A.K. Mogas, R. Olivenstein, P.O. Fiset, J. Chakir, J. Bourbeau, P. Ernst C. Lemiere, J.G. Martin, Q. Hamid. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J. Allergy Clin. Immunol. 119:863-71, 2007.

341. K. Al-Qahtani, V. Brousseau, D. Paczesny, G. Domaniowski, Q. Hamid, M. Hier, M. Black, E. Franco, K. Kost. Koilocytosis in oral squamous cell carcinoma: what does it mean? J. Otolaryngol. 36: 26-31, 2007.

342. S.C. Foley and Q. Hamid. Images in allergy and immunology: neutrophils in asthma. J. Allergy Clin. Immunol. 119: 1282-86, 2007 (Review).

343. S.C. Foley, D. Prefontaine, Q. Hamid. Images in allergy and immunology: role of eosinophils in airway remodeling. J. Allergy Clin. Immunol. 119: 1563-66, 2007.

344. S.C. Foley, Q. Hamid. Role of inflammatory T cells and eosinophils in chronic rhinosinusitis. Clin. Allergy Immunol. 20: 79-91, 2007 (Review).

345. L.P. Boulet, Q. Hamid, S.L. Bacon, C. Bergeron, Y. Chen, A.E. Dixon, P. Ernst, Q. Hamid, F. Holguyin, C.G. Irvin, R.J. Kimoff, S. Komakual, C. Laprise, K.L. Lavoie, S.A. Shore, M. Teodorescu, M.C. Vohl. Symposium on obesity and asthma – November 2, 2006. Can. Respir. J. 14: 201-8, 2007.

346. J. Bourbeau, P. Christodoulopoulos, F. Maltais, Y. Yamachi, R. Olivenstein, Q. Hamid. Effect of salmeterol/fluticasone propionate on ariway inflammation in COPD : a randomized controlled trial. Thorax, June 62: 938-943, 2007.

347. J.Shan, P. Carbonara, N. Karp, M. Tulic, Q. Hamid, D.H. Eidelman. Localization and distribution of NOS1 in murine airways. Nitric Oxide, 17: 25-32, 2007.

348. D. Prefontaine, Q. Hamid. Airway epithelial cells in asthma. J. Allergy Clin. Immunol. 2007

349. Y. Sumi, Q. Hamid. Airway remodeling in asthma. Allergol. Int. 56: 341-348, 2007.

350. L.M. Fawaz, E. Sharif-Askari, O. Hajoui, A. Soussi-Gounni, Q. Hamid, B.D. Mazer. Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion. J. Allergy Clin. Immunol. 120: 1208-1215, 2007.

351. Y. Sumi, S. Foley, S. Daigle, J. L’archeveque, R. Olivenstein, S. Letuve, J-L Malo, Q. Hamid. Structural changes and airway remodeling in occupational asthma at a mean interval of 14 years after cessation of exposure. Clin. Exp. Allergy 37: 1781-1787, 2007.

352. S. Isogai, A. Athiviraham, R.S. Fraser, R. Taha, Q. Hamid. Interferon-gamma-dependent inhibition of late allergic airway responses and eosinophilia by CD8+ gammadelta T cells. Immunology 122: 230-238, 2007.

353. J.A. Gonzalo, Y. Qiu, J.M. Lora, A. Al-Garawi, J.L. Villeval, J.A. Boyce, A.G. Martinez, G. Marquez, I. Goya, Q. Hamid, C.C. Fraser, D. Picarella, J. Cote-Sierra, M.R. Hodge, J.C. Gutierrez-Ramos, R. Kolbeck, A.J. Coyle. Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: Critical role of the CC chemokine ligand 1:CCR8 axis. J. Immunol. 179: 1740-1750, 2007.

354. J. Shannon, P. Ernst, Y. Yamauchi, R. Olivenstein, C. Lemiere, S. Foley, L. Cicora, M. Ludwig, Q. Hamid, J.G. Martin. Differences in airway cytokine profile in severe asthma compared to moderate asthma. Chest 2007.

355. P. Joubert, S. Lajoie-Kadoch, M. Welman, S. Dragon, S. Letuve, B.Tolloczko, A.J. Halayko, A.S. Gounni, K. Maghni, Q. Hamid. Expression and regulation of CCR1 by airway smooth muscle cells in asthma. J. Immunol. 2008.

356. M.E. Darveau, E.Jacques, M.Rouabhia, Q. Hamid, J. Chakir. Increased T-cell survival by structural bronchial cells derived from asthmatic subjects cultured in an engineered human mucosa. J. Allergy Clin. Immunol. 2008.

1. A.J. Wardlaw and Q. Hamid, Editors. Textbook of Respiratory Cell and Molecular Biology, U.K. 2002.

2. Hamid, Q., Shannon, J. and Martin, J.G. Physiologic Basis of Respiratory Disease, B.C. Decker, Inc., Hamilton, Ontario, 2005.

1. J.M. Polak, J. Steel, Q. Hamid, S. an Noorden, P. Jones, P. Denny, S. Legon, S.R. Bloom. Dynamic endocrinology of the pitutary gland. A study of the prolactin gene. In: Prolactin gene family and its receptors. Molecular biology to clinical problems. Proceeding of the 5th international congress on prolactin. Edited by Hoshimo K, Amsterdam, Elsevier. 1988 (chapter).

2. J. Steel, Q. Hamid, S. Van Noorden, L. Chandrachud, P. Jojnes, P. Denny, J. Burrin, A. McNicol, S. Legon, S.R. Bloom, J.M. Polak. Changes in prolactin and proopiomelanocortin mRNA in rat pituitary as shown by in situ hybridization. In; Neuroendocrine Perspectives, Volume 6 edited by MF Scanlon and JA Wass, Springer-Verlag, New York, 1989, (chapter).

3. C. Adams, Q. Hamid, J.M. Polak. In situ hybridization with radio-labelled cRNA probes,using tissues section and smears. Methods in Molecular Biology; edited by Pollard JW and Walker JM Clifton, New Jersey, Humana 1990: 501, (chapter).

4. C.J. Corrigan, Q. Hamid, A.B. Kay. Studies on bronchial asthma using the technique of in situ hybridization. In: Advances in Allergology and Clinical Immunology; eds. Ph. Godard, J. Bousquet, F.B. Michel; Parthenon Publishing, Carnforth, Lancs., chapter 17, 137-145, 1992.

5. A.B. Kay, Q. Hamid D.S. Robinson, A.M. Bentley, A. Tsicopoulos, Sun Ying, R. Moqbel, C.J. Corrigan, S.R. Durham. Asthma, eosinophils, and interleukin-5. In: Eosinophils in Allergy and Inflammation; eds. G.J. Gleich, A.B. Kay; Marcel Dekker, Inc., New York, chap.21,395-406, 1993.

6. C.J. Corrigan, A. Bentley, D.S. Robinson, Q. Hamid, Sun Ying, M. Azzawi, B. Bradley, S.R. Durham, A.B. Kay. The role of T-lymphocytes in asthma. In: New Concepts in Asthma (Proceedings of International Symposium, Castres, France, 1991); eds. J.P. Tarayre, B.Vargaftig, E.Carilla; Macmillan Press (Pierre Fabre Monograph Series), Basingstoke, Hants, chapter 13, 153-161, 1993.

7. C.J. Corrigan, Q. Hamid, A.B. Kay. T lymphocytes and the pathogenesis of bronchial asthma: studies using the techniques of in situ hybridization and polymerase chain reaction cDNA amplification. In: Asthma, Physiology, Immunopharmacology, and Treatment (Fourth International Symposium); eds. S.T. Holgate, K.F. Austen, L.M. Lichtenstein, A.B. Kay; Academic Press, London, Chapter 12, 153-162, 1993.

8. Q. Hamid. Isotopic localization of cellular mRNA in clinical material using RNA probes. In; Diagnostic Molecular Pathology: A Practical Approach Volume 1 edited by C Sy and R Herrington, IRL Press, New York, Tokyo, 1993, (chapter).

9. Q. Hamid, S. Ying, A.B. Kay. Cytokine producing cells. In: Proceedings of the INSERM International Meeting on Cytokines pp. 715-719, 1994.

10. D.Y.M. Leung, Q.A. Hamid. Immunology of atopic dermatitis. In: Atopic Dermatitis: From Pathogenesis to Treatment. Leung DYM (ed), R.G. Landes Co., Austen, 1995; pp. 111-142.

11. Q.A. Hamid, E.M. Minshall. In situ detection of cytokines in allergic inflammation. In: New Horizons in Allergy Immunotherapy. Sehon et al. (Ed), Plenum Press, New York, 1996; Chapt. 46, pp. 327-335.

12. Q. Hamid, E. Minshall. In situ detection of cytokines in allergic inflammation. Adv Exp Med & Biol. 409: 327-35, 1996

13. Q. Hamid. In situ hybridization. Allergy and Allergic Diseases, edited by A. B. Kay, Blackwell Scientific, London, UK, pp. 766-774, 1997.

14. Q. Hamid, Immunocytochemistry. Allergy and Alllergic Diseases, edited by A.B. Kay, Blackwell Scientific, London, UK, pp. 775-783, 1997

15. S. R. Durham, H. Gould, Q. A. Hamid. IgE regulation in tissues. Molecular Mechanisms Edited by D. Vercelli, John Wiley & Sons Ltd., pp. 21-36, 1997.

16. S.R. Durham, Q. A. Hamid. The effect of immunotherapy on allergen induced late responses. Regulatory control & standardization of allergenic extracts. Edited by R. Kurth, D. Haustein, Y. Lin, Gustav Fischer, pp. 33-39, 1997

17. E.D. Wright, S. Frenkiel, Q. Hamid. Immune Responses in the Chronic Inflammatory Process Within the Paranasal Sinus Mucosa. Cilia, Mucus, and Mucociliary Interactions, edited by G.J. Baum, Z. Priel, Y. Roth, N. Liron, E. Ostfield, 1998.

18. S. R. Durham, Q. Hamid. Immunological Responses to Allergen Immunotherapy. In: Eds. R.F. Lockey, S.C. Bukantz, Allergens and Allergen Immunotherapy. Second Edition, revised and expanded. Marcel Dekker Inc., Chapter 19, 1998, pp 341-357.

19. L.A. Cameron, Q.A. Hamid. T lymphocytes in allergic disease. In: Canadian Journal of Allergy & Clinical Immunology, 1998; Vol. 3, pp. 196-204.

20. R.P. Schleimer and Q.A. Hamid. Regulation of allergic airways inflammation by cytokines and glucocorticoids. In:Asthma and Allergic Diseases. Eds. G. Marone, K.F. Austen, S.T. Holgate, A.B. Kay, L.M. Lichetenstein. Academic Press, 1998; Chapter 25, pp. 337-355.

21. Q.A. Hamid. Cytokines in immulogically mediated lung diseases. In: The Allergy in Practice. Japan, 18:65-69, 1998.

22. S.R. Durham, K. Masuyama, Q. Hamid. Interleukin-5 in rhinitis: Influence of treated. In: Interleukin-5 from Molecule to Drug Target for Asthma, edited by C.J. Sanderson, vol. 125, 1998; pp39-50.

23. P. Christodoulopoulos, , D.Y.M. Leung, Q.A. Hamid. The mechanisms of steroid resistance. International Review of Asthma 1:27-39, 1999.

24. N. Daniuk, L.V. Karkanitsa, V.A. Ostapenko, N. Kroutchinsky, V.E. Shevchuk, G. Shablovsky, Q. Hamid. Correlation of levels of mRNA for interleukin-5 and individual dose of ionizing radiation in Belarusians exposed to radionuclides released during the chernobyl accident. IN: World Scientific. 1999.

26. L. Cameron and Q.A. Hamid. Neuro-endocrine tumors of the lung. Cellular and Molecular Pathogenesis of Respiratory Disease, edited by Q.A. Hamid and A.J. Wardlaw.

27. E.M.Minshall and Q.A. Hamid. The pathology of asthma. Respiratory Cell and Molecular Biology, edited by A.J. Wardlaw and Q.A. Hamid.

28. Q.A. Hamid. Role of T lymphocytes in asthma. IN: Conversations in Allergy, edited S.Meredith, UBC Institute of Allergy, 2000.

29. S. Molet and Q.A. Hamid. Effects of corticosteroids on asthma pathology. IN: Severe Asthma: A Multidisciplinary Approach, edited by S.J. Szefler and D.Y.M. Leung, Marcel Dekker Inc., 2000.

30. Y. Nakamura, P. Christodoulopoulos, Q. Hamid. Localization of IL-4 and IL-5 mRNA by in situ hybridization in bronchial biopsies. IN: Asthma: Mechanisms and Protocols, edited by K.F. Chung and I. Adcock, Humana Press Inc., 2000.

31. L. Cameron and Q. Hamid. Local IgE production in the upper and lowe respiratory mucosa. IN: Anti-IgE and Allergic Diseases, edited by R.B. Fick Jr and P.M. Jardieu, Marcel Dekker, 2000.

32. Q.A. Hamid. Advances in the pathophysiology of bronchial asthma. IN: Allergology International, Japanese Society of Allergology. (Review), 2000.

33. S. Muro, E.M. Minshall, Q.A. Hamid. The pathology of chronic asthma. IN: Clinics in Chest Medicine, edited by S. Wenzel. W.B. Saunders, 2000.

34. Q.A. Hamid and E. Minshall. Advances in the pathogenesis of asthma: Role of T cells and eosinophils. IN: Molecular mechanisms in allergy and clinical immunology, edited by L.J. Rosewasser, Mosby Inc., 2000.

35. S. Molet and Q.Hamid. Role of airway remodeling in severe asthma. IN: Severe Asthma, Pathogenesis and Clinical Management, 2nd Edition, edited by S.J. Szefler and D.Y.M. Leung, July 2001.

36. P. Christodoulopoulos, S. Muro, Q. Hamid. Molecular pathology of allergic diseases. IN: Asthma and Allergic Diseases, edited by D.S. Robinson, 2000.

37. O. Ghaffar, P. Christodoulopoulos, Q. Hamid. Cellular sources of chemokines in allergic disease. In: Chemokines in Allergic Disease, edited by M. Rothenberg.

38. E. Nutku, M. Toda, Q. Hamid. Rhinitis, nasal polyposis and asthma. IN: The Nose and Lung Diseases, European Respiratory Monograph, Vol. 6, Monograph 18, Chapter 9, pp 115-142, 2001. Edited by: B. Wallaert, P. Chanez, P. Godard.

39. E.M. Minshall, Q. Hamid. The pathology of asthma. IN: Textbook of Respiratory Cell and Molecular Biology, Chapter 4, pp 73-98, 2002, edited by A.J. Wardlaw and Q. Hamid.

40. E.M. Minshall, Q. Hamid. Molecular pathology of non-small cell carcinoma. IN: Textbook of Respiratory Cell and Molecular Biology, Chapter 17, pp 329-341, 2002, edited by A.J. Wardlaw and Q. Hamid.

41. L. Cameron and Q. Hamid. Neuroendocrine tumors of the lung. Textbook of Respiratory Cell and Molecular Biology, Chapter 18, pp 343-366, 2002, edited by A.J. Wardlaw and Q. Hamid

42. L. Cameron, Q. Hamid. Regulation of allergic airways inflammation by cytokines and glucocorticoids. Current Allergy & Asthma Reports 1: 153-163, 2001.

44. Q. Hamid, L Cameron, H Gould, S Durham. Local IgE production in the upper and lower respiratory mucosa.

45. S. Molet and Q. Hamid. Effect of steroids on the pathogenesis of asthma. In: ???, edited by DYM Leung (In preparation).

46. S.E. Sobol, P. Christodoulopoulos, Q. Hamid. Inflammatory patterns of allergic and non-allergic rhinitis.

47. M. Tulic, Q. Hamid. The Role of the Distal Lung in Asthma. Seminars in Respiratory and Critical Care Medicine, Vol. 23(4), pp. 347-359, 2002.

48. P. Christodoulopoulos, M. Tulic, M. Kontolemos, Q. Hamid. Immunopathology of allergic airway inflammation. IN: Immunopathology of Allergic Airway Inflammation. 2004.

49. Z. Muller, S. Letuve, S. Lajoie-Kadoch, Q. Hamid. Interleukin-17. (Submitted) 2005.

50. S. Muro, I. Ito, S. Foley, Q. Hamid. Interleukins: IL-15. (Submitted) 2005.

51. M.K. Tulic, P.O. Fiset, Z. Muller, Q. Hamid. Cytokines and chemokines in asthma: An overview, in Physiologic Basis of Respiratory Disease, Hamid, Q., Shannon, J, Martin, J.G. (eds.), B.C. Decker, Inc., Hamilton, Ontario, Chapter 39, pps 453-468, 2005.

52. S. Foley, Q. Hamid. Role of inflammatory T cells and eosinophils in chronic rhinosinusitis. IN: Clinical Allergy and Immunology Series; Chronic Sinusitis: Pathogenesis and Medical Management. D.L. Hamilos, F.M. Baroody, eds. Informa Healthcare, 2007; Chapter 5, pp. 79- 91.